Factors Influencing Plasma Concentrations of Valproic Acid in Pediatric Patients With Epilepsy and the Clinical Significance of CYP2C9 Genotypes in Personalized Valproic Acid Therapy

• Published in: Therapeutic drug monitoring Vol. 46; no. 4; p. 503
• Main Authors: Ma, Bingsuo, Yang, Kun, Li, Xinping, Su, Ning, Yu, Ting, Zou, Yan, Xu, Xingmeng, Wang, Fei, Cheng, Jingdong, Yan, Zijun, Chen, Tong, Zhang, Liangming
• Format: Journal Article
• Language: English
• Published: United States 01.08.2024
• Subjects: Adolescent; Anticonvulsants - blood; Anticonvulsants - pharmacokinetics; Anticonvulsants - therapeutic use; Child; Child, Preschool; Clinical Relevance; Cytochrome P-450 CYP2C9 - genetics; Drug Monitoring - methods; Epilepsy - blood; Epilepsy - drug therapy; Epilepsy - genetics; Female; Genotype; Humans; Infant; Male; Polymorphism, Genetic - genetics; Precision Medicine - methods; Retrospective Studies; Valproic Acid - blood; Valproic Acid - therapeutic use

The aim of this study was to investigate the factors affecting plasma valproic acid (VPA) concentration in pediatric patients with epilepsy and the clinical significance of CYP2C9 gene polymorphisms in personalized dosing using therapeutic drug monitoring and pharmacogenetic testing. The medical rec...