PEDF Reduces the Severity of Herpetic Simplex Keratitis in Mice

• Published in: Investigative ophthalmology & visual science Vol. 59; no. 7; pp. 2923 - 2931
• Main Authors: Tian, Xiao, Wang, Tongsong, Zhang, Songmei, Wang, Qian, Hu, Xiaoli, Ge, Cheng, Xie, Lixin, Zhou, Qingjun
• Format: Journal Article
• Language: English
• Published: United States 01.06.2018

The purpose of this study was to explore the effects of pigment epithelium derived factor (PEDF) and PEDF-derived peptides Mer44 and Mer34 on the severity of herpetic simplex keratitis (HSK) in mice. Adult C57BL/6 mice were infected ocularly with the herpes simplex virus type 1 (HSV-1, McKrae strain...