The Role of Endogenous IFN-β in the Regulation of Th17 Responses in Patients with Relapsing-Remitting Multiple Sclerosis

• Published in: The Journal of immunology (1950) Vol. 192; no. 12; pp. 5610 - 5617
• Main Authors: Tao, Yazhong, Zhang, Xin, Chopra, Manisha, Kim, Ming-Jeong, Buch, Kinnari R, Kong, Dehan, Jin, Jianping, Tang, Yunan, Zhu, Hongtu, Jewells, Valerie, Markovic-Plese, Silva
• Format: Journal Article
• Language: English
• Published: United States 15.06.2014
• Subjects: Adjuvants, Immunologic - pharmacology; Adolescent; Adult; Cytokines - immunology; Female; Humans; Interferon beta-1a; Interferon-beta - immunology; Interferon-beta - pharmacology; Male; Middle Aged; Multiple Sclerosis - immunology; Multiple Sclerosis - pathology; Receptor, Interferon alpha-beta - immunology; Recurrence; Signal Transduction - drug effects; Signal Transduction - immunology; Th17 Cells - immunology; Th17 Cells - pathology

IFN-β has been used as a first-line therapy for relapsing-remitting multiple sclerosis (RRMS). Because only a few studies have addressed the role of endogenous IFN-β in the pathogenesis of the disease, our objective was to characterize its role in the transcriptional regulation of pathogenic Th17 cy...