Pre- and postweaning indices of neurotoxicity in rats: effects of triethyltin (TET)

• Published in: Toxicology and applied pharmacology Vol. 72; no. 3; p. 557
• Main Author: Miller, D B
• Format: Journal Article
• Language: English
• Published: United States 15.03.1984
• Subjects: Animals; Animals, Newborn; Body Weight - drug effects; Female; Locomotion - drug effects; Male; Motor Activity - drug effects; Psychomotor Performance - drug effects; Rats; Trialkyltin Compounds - toxicity; Triethyltin Compounds - toxicity

Pre- and postweaning measures of learning and locomotor activity were used as indices of CNS function after early perinatal neurotoxic insult. Triethyltin (0.0, 3.0, or 6.0 mg/kg, ip) administered on Postnatal Day 5 (PND5) was used as the neurotoxicant. Learning deficits and alterations in locomotor...