Ribo- and deoxyribonucleoside effect on 3'-amino-2',3'-dideoxycytidine-induced cytotoxicity in cultured L1210 cells

• Published in: Biochemical pharmacology Vol. 32; no. 16; p. 2427
• Main Authors: Mancini, W R, Lin, T S
• Format: Journal Article
• Language: English
• Published: England 15.08.1983
• Subjects: Animals; Antineoplastic Agents - pharmacology; Cell Survival - drug effects; Cells, Cultured; Cytarabine - pharmacology; Deamination; Deoxycytidine - analogs & derivatives; Deoxycytidine - pharmacology; Deoxyribonucleosides - pharmacology; DNA, Neoplasm - biosynthesis; Leukemia L1210 - drug therapy; Leukemia L1210 - pathology; Ribonucleosides - pharmacology; Zalcitabine - analogs & derivatives

3'Amino-2',3'-dideoxycytidine (3'-NH2-dCyd) is a potent inhibitor of the replication of cultured L1210 cells, with an IC50 of 1 microM. When ribo- and deoxyribonucleosides were examined for their effects on 3'-NH2-dCyd-induced cytotoxicity, only dCyd could both prevent and r...