Controlled preparation of layered double hydroxide nanoparticles and their application as gene delivery vehicles

Layered double hydroxides (LDHs) have been known for many decades as catalyst and ceramic precursors, traps for anionic pollutants, catalysts, and additives for polymers, but they recently attracted attention as potential nano-sized carriers for therapeutic/bio-active molecules and genes. Among the...

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Published inApplied clay science Vol. 48; no. 1; pp. 280 - 289
Main Authors Ladewig, Katharina, Niebert, Marcus, Xu, Zhi Ping, Gray, Peter P., Lu, Gao Qing (Max)
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.03.2010
Subjects
Gene delivery
Layer double hydroxides
Nanoparticles
Nanoparticles
Gene delivery
Layer double hydroxides
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Abstract Layered double hydroxides (LDHs) have been known for many decades as catalyst and ceramic precursors, traps for anionic pollutants, catalysts, and additives for polymers, but they recently attracted attention as potential nano-sized carriers for therapeutic/bio-active molecules and genes. Among the many different nanoparticles that have been shown to facilitate gene and/or drug delivery, LDH nanoparticles are particularly well suited for this purpose due to their many desirable properties. In this research Mg 2Al(OH) 6NO 3 LDH nanoparticles of varying lateral sizes were synthesized by altering the synthesis conditions. The synthesis conditions particularly influencing the particle size distribution of the LDH suspensions are (a) the temperature during the co-precipitation step and (b) the duration and the temperature of the hydrothermal treatment. The association of these nanoparticles with plasmid DNA was studied and it was established that–in contrast to previously published reports–for the plasmid sizes used no significant intercalation occurs. The plasmids wrap around individual particles instead and aggregation of particles is observed. However, due to the observed strong interaction between LDH nanoparticles and DNA, the particles were nonetheless evaluated as transfection agents for mammalian cells. Considerable transfection efficiencies when transfecting adherent cell lines (i.e., HEK293T, NIH 3T3, COS-7, and CHO-K1) were observed, while the transfection of suspension CHO-S cells remained unsuccessful. This is attributed to the formation of aggregates upon DNA–LDH complex formation which settle on top of adherent cells but due to the constant agitation of suspension cultures not on the surface of e.g., CHO-S cells.
AbstractList Layered double hydroxides (LDHs) have been known for many decades as catalyst and ceramic precursors, traps for anionic pollutants, catalysts, and additives for polymers, but they recently attracted attention as potential nano-sized carriers for therapeutic/bio-active molecules and genes. Among the many different nanoparticles that have been shown to facilitate gene and/or drug delivery, LDH nanoparticles are particularly well suited for this purpose due to their many desirable properties. In this research Mg sub(2)Al(OH) sub(6)NO sub(3) LDH nanoparticles of varying lateral sizes were synthesized by altering the synthesis conditions. The synthesis conditions particularly influencing the particle size distribution of the LDH suspensions are (a) the temperature during the co-precipitation step and (b) the duration and the temperature of the hydrothermal treatment. The association of these nanoparticles with plasmid DNA was studied and it was established that-in contrast to previously published reports-for the plasmid sizes used no significant intercalation occurs. The plasmids wrap around individual particles instead and aggregation of particles is observed. However, due to the observed strong interaction between LDH nanoparticles and DNA, the particles were nonetheless evaluated as transfection agents for mammalian cells. Considerable transfection efficiencies when transfecting adherent cell lines (i.e., HEK293T, NIH 3T3, COS-7, and CHO-K1) were observed, while the transfection of suspension CHO-S cells remained unsuccessful. This is attributed to the formation of aggregates upon DNA-LDH complex formation which settle on top of adherent cells but due to the constant agitation of suspension cultures not on the surface of e.g., CHO-S cells.
Layered double hydroxides (LDHs) have been known for many decades as catalyst and ceramic precursors, traps for anionic pollutants, catalysts, and additives for polymers, but they recently attracted attention as potential nano-sized carriers for therapeutic/bio-active molecules and genes. Among the many different nanoparticles that have been shown to facilitate gene and/or drug delivery, LDH nanoparticles are particularly well suited for this purpose due to their many desirable properties. In this research Mg 2Al(OH) 6NO 3 LDH nanoparticles of varying lateral sizes were synthesized by altering the synthesis conditions. The synthesis conditions particularly influencing the particle size distribution of the LDH suspensions are (a) the temperature during the co-precipitation step and (b) the duration and the temperature of the hydrothermal treatment. The association of these nanoparticles with plasmid DNA was studied and it was established that–in contrast to previously published reports–for the plasmid sizes used no significant intercalation occurs. The plasmids wrap around individual particles instead and aggregation of particles is observed. However, due to the observed strong interaction between LDH nanoparticles and DNA, the particles were nonetheless evaluated as transfection agents for mammalian cells. Considerable transfection efficiencies when transfecting adherent cell lines (i.e., HEK293T, NIH 3T3, COS-7, and CHO-K1) were observed, while the transfection of suspension CHO-S cells remained unsuccessful. This is attributed to the formation of aggregates upon DNA–LDH complex formation which settle on top of adherent cells but due to the constant agitation of suspension cultures not on the surface of e.g., CHO-S cells.
Author Xu, Zhi Ping
Gray, Peter P.
Ladewig, Katharina
Niebert, Marcus
Lu, Gao Qing (Max)
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  surname: Ladewig
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  surname: Niebert
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  givenname: Zhi Ping
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  givenname: Gao Qing (Max)
  surname: Lu
  fullname: Lu, Gao Qing (Max)
  email: maxlu@uq.edu.au
  organization: ARC Centre of Excellence for Functional Nanomaterials, Australian Institute for Bioengineering and Nanotechnology and School of Engineering, The University of Queensland, Brisbane, QLD 4072, Australia
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Cites_doi 10.1021/cm703602t
10.1517/17425247.5.2.189
10.1021/ja056652a
10.1016/j.jconrel.2004.07.035
10.1517/17425240903130585
10.2174/1573413710602030275
10.1002/9783527621446.ch13
10.1016/0169-1317(95)00010-2
10.1055/s-2002-20447
10.1039/b505014f
10.1039/B204076J
10.1016/0920-5861(91)80068-K
10.1002/1521-4095(200108)13:16<1263::AID-ADMA1263>3.0.CO;2-R
10.1103/PhysRevE.65.051903
10.1021/jp062281o
10.1557/mrs2004.14
10.1021/cm0110268
10.1016/0926-3373(96)90072-7
10.1016/j.biomaterials.2003.09.083
10.1016/j.jconrel.2003.12.027
10.1021/cm048085g
10.1021/nl052020a
10.1016/0025-5408(89)90193-1
10.1016/j.biomaterials.2009.10.058
10.1351/pac200678091771
10.2174/1573413710602030283
10.1016/j.clay.2006.06.010
10.1016/j.jconrel.2008.05.021
10.1081/CR-120001809
10.4028/www.scientific.net/SSP.111.1
10.1021/bc0601323
10.1016/S0010-8545(98)00216-1
10.1016/j.ces.2005.06.019
10.1504/IJNT.2006.011178
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Keywords Nanoparticles
Gene delivery
Layer double hydroxides
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References Del Hoyo (bib13) 2007; 36
Leroux, Taviot-Gueho (bib26) 2005; 15
Ren, Wan, Duan (bib30) 2006; 3
Choy, Kwak, Jeong, Park (bib7) 2000; 39
Xu, Lu (bib40) 2005; 17
Sofou, Sgouros (bib33) 2008; 5
Forano, Vial, Mousty (bib15) 2006; 2
Woltermann, G.M., 1984. Expanded layered minerals. (Ashland Oil, Inc., USA). Application: US Patent 83-479418, 5 pp.
Choy (bib10) 2006; 111
Xu, Stevenson, Lu, Lu (bib43) 2006; 110
Xu (bib45) 2007; 2
Xu, Lu (bib41) 2006; 78
Ladewig, Xu, Lu (bib24) 2009; 6
Woolard (bib38) 2002; 65
Rives, Angeles Ulibarri (bib31) 1999; 181
Ladewig, K., 2009. Nanoparticles with Application in the Delivery of Nucleic Acids to Mammalian Cells. PhD thesis, The University of Queensland, Australia.
Broecker, F.J. and Marosi, L., 1971. Catalysts with very fine distribution of active components. (Badische Anilin- & Soda-Fabrik AG). Application: DE Patent 70-2024282, 27 pp.
Choy, Park, Oh (bib9) 2006; 2
Gardner, Huntoon, Pinnavaia (bib16) 2001; 13
Tyner (bib35) 2004; 100
Xu (bib44) 2006; 128
Trifiro, Vaccari (bib34) 1996; 7
Khan, O'Hare (bib20) 2002; 12
Oh, Choi, Kim, Choy (bib28) 2006; 17
Choy, J.-H., Oh, J.-M. and Choi, S.-J., 2008. Bio-inorganic conjugates for drug and gene delivery, Bio-Inorganic Hybrid Nanomaterials, pp. 401–418.
Ladewig, K., Niebert, M., Xu, Z.P., Gray, P., Lu, G.Q., 2009a. Efficient siRNA delivery to mammalian cells using layered double hydroxide nanoparticles. Biomaterials.
Pinnavaia, Chibwe, Constantino, Yun (bib29) 1995; 10
Sels, De Vos, Jacobs (bib32) 2001; 43
Xu, Hu, Wang (bib39) 1997; 6
Desigaux (bib14) 2006; 6
Kriven, Kwak, Wallig, Choy (bib21) 2004; 29
Choy (bib6) 2004; 25
.
Braterman, Xu, Yarberry (bib2) 2004
Gu, Thomas, Xu, Campbell, Lu (bib17) 2008; 20
Choy, Park (bib11) 2005; 12
Leroux, Besse (bib25) 2001; 13
Kameshima (bib18) 2007; 20
Newman, Jones (bib27) 2002
Yamaoka, Abe, Tsuji (bib47) 1989; 24
Aisawa (bib1) 2002; 55
Braterman, Xu, Yarberry (bib3) 2004
De Vos, D.E., Wahlen, J., Sels, B.F. and Jacobs, P.A., 2002. Peroxide reactions with anion-exchanged layered double hydroxide catalysts. Synlett(3): 367–380.
Kapteijn, Rodriguez-Mirasol, Moulijn (bib19) 1996; 9
Tyner, Schiffman, Giannelis (bib36) 2004; 95
Xu (bib42) 2008; 130
Xu, Zeng, Lu, Yu (bib46) 2006; 61
Cavani, Trifiro, Vaccari (bib5) 1991; 11
Ren (10.1016/j.clay.2009.11.032_bib30) 2006; 3
Sels (10.1016/j.clay.2009.11.032_bib32) 2001; 43
Leroux (10.1016/j.clay.2009.11.032_bib25) 2001; 13
Xu (10.1016/j.clay.2009.11.032_bib40) 2005; 17
Tyner (10.1016/j.clay.2009.11.032_bib35) 2004; 100
Oh (10.1016/j.clay.2009.11.032_bib28) 2006; 17
Kameshima (10.1016/j.clay.2009.11.032_bib18) 2007; 20
Braterman (10.1016/j.clay.2009.11.032_bib2) 2004
10.1016/j.clay.2009.11.032_bib12
Gu (10.1016/j.clay.2009.11.032_bib17) 2008; 20
10.1016/j.clay.2009.11.032_bib37
Newman (10.1016/j.clay.2009.11.032_bib27) 2002
Pinnavaia (10.1016/j.clay.2009.11.032_bib29) 1995; 10
Trifiro (10.1016/j.clay.2009.11.032_bib34) 1996; 7
Xu (10.1016/j.clay.2009.11.032_bib41) 2006; 78
Choy (10.1016/j.clay.2009.11.032_bib11) 2005; 12
Xu (10.1016/j.clay.2009.11.032_bib45) 2007; 2
10.1016/j.clay.2009.11.032_bib8
Xu (10.1016/j.clay.2009.11.032_bib43) 2006; 110
Kriven (10.1016/j.clay.2009.11.032_bib21) 2004; 29
Forano (10.1016/j.clay.2009.11.032_bib15) 2006; 2
Choy (10.1016/j.clay.2009.11.032_bib9) 2006; 2
Tyner (10.1016/j.clay.2009.11.032_bib36) 2004; 95
Leroux (10.1016/j.clay.2009.11.032_bib26) 2005; 15
Xu (10.1016/j.clay.2009.11.032_bib44) 2006; 128
10.1016/j.clay.2009.11.032_bib4
Choy (10.1016/j.clay.2009.11.032_bib6) 2004; 25
Rives (10.1016/j.clay.2009.11.032_bib31) 1999; 181
Aisawa (10.1016/j.clay.2009.11.032_bib1) 2002; 55
Cavani (10.1016/j.clay.2009.11.032_bib5) 1991; 11
Del Hoyo (10.1016/j.clay.2009.11.032_bib13) 2007; 36
Yamaoka (10.1016/j.clay.2009.11.032_bib47) 1989; 24
Sofou (10.1016/j.clay.2009.11.032_bib33) 2008; 5
10.1016/j.clay.2009.11.032_bib23
Gardner (10.1016/j.clay.2009.11.032_bib16) 2001; 13
Choy (10.1016/j.clay.2009.11.032_bib7) 2000; 39
Desigaux (10.1016/j.clay.2009.11.032_bib14) 2006; 6
Kapteijn (10.1016/j.clay.2009.11.032_bib19) 1996; 9
Xu (10.1016/j.clay.2009.11.032_bib39) 1997; 6
Xu (10.1016/j.clay.2009.11.032_bib42) 2008; 130
Braterman (10.1016/j.clay.2009.11.032_bib3) 2004
Ladewig (10.1016/j.clay.2009.11.032_bib24) 2009; 6
Woolard (10.1016/j.clay.2009.11.032_bib38) 2002; 65
Khan (10.1016/j.clay.2009.11.032_bib20) 2002; 12
Choy (10.1016/j.clay.2009.11.032_bib10) 2006; 111
10.1016/j.clay.2009.11.032_bib22
Xu (10.1016/j.clay.2009.11.032_bib46) 2006; 61
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  start-page: 1771
  year: 2006
  end-page: 1779
  ident: bib41
  article-title: Layered double hydroxide nanomaterials as potential cellular drug delivery agents
  publication-title: Pure and Applied Chemistry
  contributor:
    fullname: Lu
– volume: 3
  start-page: 545
  year: 2006
  end-page: 556
  ident: bib30
  article-title: Bio-active molecule immobilisation on layered double hydroxides
  publication-title: International Journal of Nanotechnology
  contributor:
    fullname: Duan
– volume: 2
  start-page: 275
  year: 2006
  end-page: 281
  ident: bib9
  article-title: Bio-nanohybrids based on layered double hydroxide
  publication-title: Current Nanoscience
  contributor:
    fullname: Oh
– volume: 20
  start-page: 3715
  year: 2008
  end-page: 3722
  ident: bib17
  article-title: In vitro sustained release of LMWH from MgAl-layered double hydroxide nanohybrids
  publication-title: Chemistry of Materials
  contributor:
    fullname: Lu
– volume: 7
  start-page: 251
  year: 1996
  end-page: 291
  ident: bib34
  article-title: Hydrotalcite-like anionic clays (layered double hydroxides)
  publication-title: Comprehensive Supramolecular Chemistry
  contributor:
    fullname: Vaccari
– start-page: 373
  year: 2004
  end-page: 474
  ident: bib2
  publication-title: Layered double hydroxides (LDHs) in Handbook of Layered Material
  contributor:
    fullname: Yarberry
– start-page: 373
  year: 2004
  end-page: 474
  ident: bib3
  publication-title: Layered double hydroxides (LDHs). Handbook of Layered Materials
  contributor:
    fullname: Yarberry
– volume: 11
  start-page: 173
  year: 1991
  end-page: 301
  ident: bib5
  article-title: Hydrotalcite-type anionic clays: preparation, properties and applications
  publication-title: Catalysis Today
  contributor:
    fullname: Vaccari
– volume: 24
  start-page: 1183
  year: 1989
  end-page: 1199
  ident: bib47
  article-title: Synthesis of copper–aluminum hydrotalcite like compound and its ion exchange property
  publication-title: Materials Research Bulletin
  contributor:
    fullname: Tsuji
– volume: 55
  start-page: 809-809
  year: 2002
  ident: bib1
  article-title: Nucleotide transport efficiency to leukemia cells by layered double hydroxide
  publication-title: Kagaku to Kogyo
  contributor:
    fullname: Aisawa
– volume: 2
  start-page: 283
  year: 2006
  end-page: 294
  ident: bib15
  article-title: Nanohybrid enzymes–layered double hydroxides: potential applications
  publication-title: Current Nanoscience
  contributor:
    fullname: Mousty
– volume: 17
  start-page: 1055
  year: 2005
  end-page: 1062
  ident: bib40
  article-title: Hydrothermal synthesis of layered double hydroxides (LDHs) from mixed MgO and Al
  publication-title: Chemistry of Materials
  contributor:
    fullname: Lu
– volume: 6
  start-page: 199
  year: 2006
  end-page: 204
  ident: bib14
  article-title: Self-assembly and characterization of layered double hydroxide/DNA hybrids
  publication-title: Nano Letters
  contributor:
    fullname: Desigaux
– volume: 20
  start-page: 101
  year: 2007
  end-page: 103
  ident: bib18
  article-title: Eco-friendly layer structures materials: layered double hydroxides (LDH)
  publication-title: Materials Integration
  contributor:
    fullname: Kameshima
– volume: 6
  start-page: 907
  year: 2009
  end-page: 922
  ident: bib24
  article-title: Layered double hydroxide nanoparticles in gene and drug delivery
  publication-title: Expert Opinion in Drug Delivery
  contributor:
    fullname: Lu
– volume: 17
  start-page: 1411
  year: 2006
  end-page: 1417
  ident: bib28
  article-title: Cellular uptake mechanism of an inorganic nanovehicle and its drug conjugates: enhanced efficacy due to clathrin-mediated endocytosis
  publication-title: Bioconjugate Chemistry
  contributor:
    fullname: Choy
– volume: 10
  start-page: 117
  year: 1995
  end-page: 129
  ident: bib29
  article-title: Organic chemical conversions catalyzed by intercalated layered double hydroxides (LDHs)
  publication-title: Applied Clay Science
  contributor:
    fullname: Yun
– volume: 2
  start-page: 163
  year: 2007
  end-page: 174
  ident: bib45
  article-title: Layered double hydroxide nanoparticles as cellular delivery vectors of supercoiled plasmid DNA
  publication-title: International Journal of Nanomedicine
  contributor:
    fullname: Xu
– volume: 36
  start-page: 103
  year: 2007
  end-page: 121
  ident: bib13
  article-title: Layered double hydroxides and human health: an overview
  publication-title: Applied Clay Science
  contributor:
    fullname: Del Hoyo
– volume: 100
  start-page: 399
  year: 2004
  end-page: 409
  ident: bib35
  article-title: Intercalation, delivery, and expression of the gene encoding green fluorescence protein utilizing nanobiohybrids
  publication-title: Journal of Controlled Release
  contributor:
    fullname: Tyner
– volume: 6
  start-page: 155
  year: 1997
  end-page: 168
  ident: bib39
  article-title: Advances in study of a new class of pillared layered microporous materials—polyoxometalate-type hydrotalcite-like catalysts
  publication-title: Journal of Natural Gas Chemistry
  contributor:
    fullname: Wang
– volume: 13
  start-page: 1263
  year: 2001
  end-page: 1266
  ident: bib16
  article-title: Direct synthesis of alkoxide-intercalated derivatives of hydrotalcite-like layered double hydroxides: precursors for the formation of colloidal layered double hydroxide suspensions and transparent thin films
  publication-title: Advanced Materials (Weinheim, Germany)
  contributor:
    fullname: Pinnavaia
– volume: 29
  start-page: 33
  year: 2004
  end-page: 37
  ident: bib21
  article-title: Bio-resorbable nanoceramics for gene and drug delivery
  publication-title: MRS Bulletin
  contributor:
    fullname: Choy
– start-page: 295
  year: 2002
  end-page: 331
  ident: bib27
  article-title: Layered double hydroxides as templates for the formation of supramolecular structures
  publication-title: Supramolecular Organization and Materials Design
  contributor:
    fullname: Jones
– volume: 13
  start-page: 3507
  year: 2001
  end-page: 3515
  ident: bib25
  article-title: Polymer interleaved layered double hydroxide: a new emerging class of nanocomposites
  publication-title: Chemistry of Materials
  contributor:
    fullname: Besse
– volume: 128
  start-page: 36
  year: 2006
  end-page: 37
  ident: bib44
  article-title: Stable suspension of layered double hydroxide nanoparticles in aqueous solution
  publication-title: Journal of the American Chemical Society
  contributor:
    fullname: Xu
– volume: 61
  start-page: 1027
  year: 2006
  end-page: 1040
  ident: bib46
  article-title: Inorganic nanoparticles as carriers for efficient cellular delivery
  publication-title: Chemical Engineering Science
  contributor:
    fullname: Yu
– volume: 25
  start-page: 3059
  year: 2004
  end-page: 3064
  ident: bib6
  article-title: Layered double hydroxide as an efficient drug reservoir for folate derivatives
  publication-title: Biomaterials
  contributor:
    fullname: Choy
– volume: 12
  start-page: 3191
  year: 2002
  end-page: 3198
  ident: bib20
  article-title: Intercalation chemistry of layered double hydroxides: recent developments and applications
  publication-title: Journal of Materials Chemistry
  contributor:
    fullname: O'Hare
– volume: 5
  start-page: 189
  year: 2008
  end-page: 204
  ident: bib33
  article-title: Antibody-targeted liposomes in cancer therapy and imaging
  publication-title: Expert Opinion on Drug Delivery
  contributor:
    fullname: Sgouros
– volume: 12
  start-page: 52
  year: 2005
  end-page: 56
  ident: bib11
  article-title: Nanohybridization of biomolecules with layered double hydroxides and hydroxy double salts for advanced applications
  publication-title: Clay Science
  contributor:
    fullname: Park
– volume: 110
  start-page: 16923
  year: 2006
  end-page: 16929
  ident: bib43
  article-title: Dispersion and size control of layered double hydroxide nanoparticles in aqueous solutions
  publication-title: Journal of Physical Chemistry B
  contributor:
    fullname: Lu
– volume: 39
  start-page: 4042
  year: 2000
  end-page: 4045
  ident: bib7
  article-title: Inorganic layered double hydroxides as nonviral vectors
  publication-title: Angewandte Chemie, International Edition
  contributor:
    fullname: Park
– volume: 181
  start-page: 61
  year: 1999
  end-page: 120
  ident: bib31
  article-title: Layered double hydroxides intercalated with metal coordination compounds and oxometalates
  publication-title: Coordination Chemistry Reviews
  contributor:
    fullname: Angeles Ulibarri
– volume: 65
  start-page: 051903
  year: 2002
  ident: bib38
  article-title: Submillimeter-wave phonon modes in DNA macromolecules
  publication-title: Physical Review E
  contributor:
    fullname: Woolard
– volume: 111
  start-page: 1
  year: 2006
  end-page: 6
  ident: bib10
  article-title: Biological hybrid materials for drug delivery system
  publication-title: Diffusion and Defect Data-Solid State Data, Pt. B: Solid State Phenomena
  contributor:
    fullname: Choy
– volume: 15
  start-page: 3628
  year: 2005
  end-page: 3642
  ident: bib26
  article-title: Fine tuning between organic and inorganic host structure: new trends in layered double hydroxide hybrid assemblies
  publication-title: Journal of Materials Chemistry
  contributor:
    fullname: Taviot-Gueho
– volume: 95
  start-page: 501
  year: 2004
  end-page: 514
  ident: bib36
  article-title: Nanobiohybrids as delivery vehicles for camptothecin
  publication-title: Journal of Controlled Release
  contributor:
    fullname: Giannelis
– volume: 130
  start-page: 86
  year: 2008
  end-page: 94
  ident: bib42
  article-title: Subcellular compartment targeting of layered double hydroxide nanoparticles
  publication-title: Journal of Controlled Release
  contributor:
    fullname: Xu
– volume: 9
  start-page: 25
  year: 1996
  end-page: 64
  ident: bib19
  article-title: Heterogeneous catalytic decomposition of nitrous oxide
  publication-title: Applied Catalysis, B: Environmental
  contributor:
    fullname: Moulijn
– volume: 43
  start-page: 443
  year: 2001
  end-page: 488
  ident: bib32
  article-title: Hydrotalcite-like anionic clays in catalytic organic reactions
  publication-title: Catalysis Reviews — Science and Engineering
  contributor:
    fullname: Jacobs
– volume: 20
  start-page: 3715
  issue: 11
  year: 2008
  ident: 10.1016/j.clay.2009.11.032_bib17
  article-title: In vitro sustained release of LMWH from MgAl-layered double hydroxide nanohybrids
  publication-title: Chemistry of Materials
  doi: 10.1021/cm703602t
  contributor:
    fullname: Gu
– volume: 5
  start-page: 189
  issue: 2
  year: 2008
  ident: 10.1016/j.clay.2009.11.032_bib33
  article-title: Antibody-targeted liposomes in cancer therapy and imaging
  publication-title: Expert Opinion on Drug Delivery
  doi: 10.1517/17425247.5.2.189
  contributor:
    fullname: Sofou
– volume: 128
  start-page: 36
  issue: 1
  year: 2006
  ident: 10.1016/j.clay.2009.11.032_bib44
  article-title: Stable suspension of layered double hydroxide nanoparticles in aqueous solution
  publication-title: Journal of the American Chemical Society
  doi: 10.1021/ja056652a
  contributor:
    fullname: Xu
– volume: 20
  start-page: 101
  issue: 7,8
  year: 2007
  ident: 10.1016/j.clay.2009.11.032_bib18
  article-title: Eco-friendly layer structures materials: layered double hydroxides (LDH)
  publication-title: Materials Integration
  contributor:
    fullname: Kameshima
– volume: 100
  start-page: 399
  issue: 3
  year: 2004
  ident: 10.1016/j.clay.2009.11.032_bib35
  article-title: Intercalation, delivery, and expression of the gene encoding green fluorescence protein utilizing nanobiohybrids
  publication-title: Journal of Controlled Release
  doi: 10.1016/j.jconrel.2004.07.035
  contributor:
    fullname: Tyner
– volume: 6
  start-page: 907
  issue: 9
  year: 2009
  ident: 10.1016/j.clay.2009.11.032_bib24
  article-title: Layered double hydroxide nanoparticles in gene and drug delivery
  publication-title: Expert Opinion in Drug Delivery
  doi: 10.1517/17425240903130585
  contributor:
    fullname: Ladewig
– volume: 2
  start-page: 275
  issue: 3
  year: 2006
  ident: 10.1016/j.clay.2009.11.032_bib9
  article-title: Bio-nanohybrids based on layered double hydroxide
  publication-title: Current Nanoscience
  doi: 10.2174/1573413710602030275
  contributor:
    fullname: Choy
– ident: 10.1016/j.clay.2009.11.032_bib4
– volume: 39
  start-page: 4042
  issue: 22
  year: 2000
  ident: 10.1016/j.clay.2009.11.032_bib7
  article-title: Inorganic layered double hydroxides as nonviral vectors
  publication-title: Angewandte Chemie, International Edition
  contributor:
    fullname: Choy
– ident: 10.1016/j.clay.2009.11.032_bib8
  doi: 10.1002/9783527621446.ch13
– volume: 12
  start-page: 52
  issue: Suppl. 1
  year: 2005
  ident: 10.1016/j.clay.2009.11.032_bib11
  article-title: Nanohybridization of biomolecules with layered double hydroxides and hydroxy double salts for advanced applications
  publication-title: Clay Science
  contributor:
    fullname: Choy
– volume: 10
  start-page: 117
  issue: 1–2
  year: 1995
  ident: 10.1016/j.clay.2009.11.032_bib29
  article-title: Organic chemical conversions catalyzed by intercalated layered double hydroxides (LDHs)
  publication-title: Applied Clay Science
  doi: 10.1016/0169-1317(95)00010-2
  contributor:
    fullname: Pinnavaia
– start-page: 373
  year: 2004
  ident: 10.1016/j.clay.2009.11.032_bib2
  contributor:
    fullname: Braterman
– ident: 10.1016/j.clay.2009.11.032_bib12
  doi: 10.1055/s-2002-20447
– volume: 15
  start-page: 3628
  issue: 35–36
  year: 2005
  ident: 10.1016/j.clay.2009.11.032_bib26
  article-title: Fine tuning between organic and inorganic host structure: new trends in layered double hydroxide hybrid assemblies
  publication-title: Journal of Materials Chemistry
  doi: 10.1039/b505014f
  contributor:
    fullname: Leroux
– volume: 12
  start-page: 3191
  issue: 11
  year: 2002
  ident: 10.1016/j.clay.2009.11.032_bib20
  article-title: Intercalation chemistry of layered double hydroxides: recent developments and applications
  publication-title: Journal of Materials Chemistry
  doi: 10.1039/B204076J
  contributor:
    fullname: Khan
– volume: 11
  start-page: 173
  issue: 2
  year: 1991
  ident: 10.1016/j.clay.2009.11.032_bib5
  article-title: Hydrotalcite-type anionic clays: preparation, properties and applications
  publication-title: Catalysis Today
  doi: 10.1016/0920-5861(91)80068-K
  contributor:
    fullname: Cavani
– volume: 13
  start-page: 1263
  issue: 16
  year: 2001
  ident: 10.1016/j.clay.2009.11.032_bib16
  article-title: Direct synthesis of alkoxide-intercalated derivatives of hydrotalcite-like layered double hydroxides: precursors for the formation of colloidal layered double hydroxide suspensions and transparent thin films
  publication-title: Advanced Materials (Weinheim, Germany)
  doi: 10.1002/1521-4095(200108)13:16<1263::AID-ADMA1263>3.0.CO;2-R
  contributor:
    fullname: Gardner
– volume: 65
  start-page: 051903
  issue: 5
  year: 2002
  ident: 10.1016/j.clay.2009.11.032_bib38
  article-title: Submillimeter-wave phonon modes in DNA macromolecules
  publication-title: Physical Review E
  doi: 10.1103/PhysRevE.65.051903
  contributor:
    fullname: Woolard
– volume: 110
  start-page: 16923
  issue: 34
  year: 2006
  ident: 10.1016/j.clay.2009.11.032_bib43
  article-title: Dispersion and size control of layered double hydroxide nanoparticles in aqueous solutions
  publication-title: Journal of Physical Chemistry B
  doi: 10.1021/jp062281o
  contributor:
    fullname: Xu
– volume: 29
  start-page: 33
  issue: 1
  year: 2004
  ident: 10.1016/j.clay.2009.11.032_bib21
  article-title: Bio-resorbable nanoceramics for gene and drug delivery
  publication-title: MRS Bulletin
  doi: 10.1557/mrs2004.14
  contributor:
    fullname: Kriven
– volume: 13
  start-page: 3507
  issue: 10
  year: 2001
  ident: 10.1016/j.clay.2009.11.032_bib25
  article-title: Polymer interleaved layered double hydroxide: a new emerging class of nanocomposites
  publication-title: Chemistry of Materials
  doi: 10.1021/cm0110268
  contributor:
    fullname: Leroux
– volume: 9
  start-page: 25
  issue: 1–4
  year: 1996
  ident: 10.1016/j.clay.2009.11.032_bib19
  article-title: Heterogeneous catalytic decomposition of nitrous oxide
  publication-title: Applied Catalysis, B: Environmental
  doi: 10.1016/0926-3373(96)90072-7
  contributor:
    fullname: Kapteijn
– ident: 10.1016/j.clay.2009.11.032_bib22
– volume: 25
  start-page: 3059
  issue: 15
  year: 2004
  ident: 10.1016/j.clay.2009.11.032_bib6
  article-title: Layered double hydroxide as an efficient drug reservoir for folate derivatives
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2003.09.083
  contributor:
    fullname: Choy
– volume: 95
  start-page: 501
  issue: 3
  year: 2004
  ident: 10.1016/j.clay.2009.11.032_bib36
  article-title: Nanobiohybrids as delivery vehicles for camptothecin
  publication-title: Journal of Controlled Release
  doi: 10.1016/j.jconrel.2003.12.027
  contributor:
    fullname: Tyner
– volume: 17
  start-page: 1055
  issue: 5
  year: 2005
  ident: 10.1016/j.clay.2009.11.032_bib40
  article-title: Hydrothermal synthesis of layered double hydroxides (LDHs) from mixed MgO and Al2O3: LDH formation mechanism
  publication-title: Chemistry of Materials
  doi: 10.1021/cm048085g
  contributor:
    fullname: Xu
– volume: 2
  start-page: 163
  issue: 2
  year: 2007
  ident: 10.1016/j.clay.2009.11.032_bib45
  article-title: Layered double hydroxide nanoparticles as cellular delivery vectors of supercoiled plasmid DNA
  publication-title: International Journal of Nanomedicine
  contributor:
    fullname: Xu
– volume: 6
  start-page: 199
  issue: 2
  year: 2006
  ident: 10.1016/j.clay.2009.11.032_bib14
  article-title: Self-assembly and characterization of layered double hydroxide/DNA hybrids
  publication-title: Nano Letters
  doi: 10.1021/nl052020a
  contributor:
    fullname: Desigaux
– volume: 24
  start-page: 1183
  issue: 10
  year: 1989
  ident: 10.1016/j.clay.2009.11.032_bib47
  article-title: Synthesis of copper–aluminum hydrotalcite like compound and its ion exchange property
  publication-title: Materials Research Bulletin
  doi: 10.1016/0025-5408(89)90193-1
  contributor:
    fullname: Yamaoka
– ident: 10.1016/j.clay.2009.11.032_bib23
  doi: 10.1016/j.biomaterials.2009.10.058
– volume: 78
  start-page: 1771
  issue: 9
  year: 2006
  ident: 10.1016/j.clay.2009.11.032_bib41
  article-title: Layered double hydroxide nanomaterials as potential cellular drug delivery agents
  publication-title: Pure and Applied Chemistry
  doi: 10.1351/pac200678091771
  contributor:
    fullname: Xu
– volume: 2
  start-page: 283
  issue: 3
  year: 2006
  ident: 10.1016/j.clay.2009.11.032_bib15
  article-title: Nanohybrid enzymes–layered double hydroxides: potential applications
  publication-title: Current Nanoscience
  doi: 10.2174/1573413710602030283
  contributor:
    fullname: Forano
– volume: 36
  start-page: 103
  issue: 1–3
  year: 2007
  ident: 10.1016/j.clay.2009.11.032_bib13
  article-title: Layered double hydroxides and human health: an overview
  publication-title: Applied Clay Science
  doi: 10.1016/j.clay.2006.06.010
  contributor:
    fullname: Del Hoyo
– ident: 10.1016/j.clay.2009.11.032_bib37
– volume: 6
  start-page: 155
  issue: 2
  year: 1997
  ident: 10.1016/j.clay.2009.11.032_bib39
  article-title: Advances in study of a new class of pillared layered microporous materials—polyoxometalate-type hydrotalcite-like catalysts
  publication-title: Journal of Natural Gas Chemistry
  contributor:
    fullname: Xu
– volume: 130
  start-page: 86
  issue: 1
  year: 2008
  ident: 10.1016/j.clay.2009.11.032_bib42
  article-title: Subcellular compartment targeting of layered double hydroxide nanoparticles
  publication-title: Journal of Controlled Release
  doi: 10.1016/j.jconrel.2008.05.021
  contributor:
    fullname: Xu
– volume: 43
  start-page: 443
  issue: 4
  year: 2001
  ident: 10.1016/j.clay.2009.11.032_bib32
  article-title: Hydrotalcite-like anionic clays in catalytic organic reactions
  publication-title: Catalysis Reviews — Science and Engineering
  doi: 10.1081/CR-120001809
  contributor:
    fullname: Sels
– volume: 111
  start-page: 1
  year: 2006
  ident: 10.1016/j.clay.2009.11.032_bib10
  article-title: Biological hybrid materials for drug delivery system
  publication-title: Diffusion and Defect Data-Solid State Data, Pt. B: Solid State Phenomena
  doi: 10.4028/www.scientific.net/SSP.111.1
  contributor:
    fullname: Choy
– volume: 17
  start-page: 1411
  issue: 6
  year: 2006
  ident: 10.1016/j.clay.2009.11.032_bib28
  article-title: Cellular uptake mechanism of an inorganic nanovehicle and its drug conjugates: enhanced efficacy due to clathrin-mediated endocytosis
  publication-title: Bioconjugate Chemistry
  doi: 10.1021/bc0601323
  contributor:
    fullname: Oh
– start-page: 373
  year: 2004
  ident: 10.1016/j.clay.2009.11.032_bib3
  contributor:
    fullname: Braterman
– start-page: 295
  year: 2002
  ident: 10.1016/j.clay.2009.11.032_bib27
  article-title: Layered double hydroxides as templates for the formation of supramolecular structures
  publication-title: Supramolecular Organization and Materials Design
  contributor:
    fullname: Newman
– volume: 181
  start-page: 61
  year: 1999
  ident: 10.1016/j.clay.2009.11.032_bib31
  article-title: Layered double hydroxides intercalated with metal coordination compounds and oxometalates
  publication-title: Coordination Chemistry Reviews
  doi: 10.1016/S0010-8545(98)00216-1
  contributor:
    fullname: Rives
– volume: 61
  start-page: 1027
  issue: 3
  year: 2006
  ident: 10.1016/j.clay.2009.11.032_bib46
  article-title: Inorganic nanoparticles as carriers for efficient cellular delivery
  publication-title: Chemical Engineering Science
  doi: 10.1016/j.ces.2005.06.019
  contributor:
    fullname: Xu
– volume: 55
  start-page: 809-809
  issue: 7
  year: 2002
  ident: 10.1016/j.clay.2009.11.032_bib1
  article-title: Nucleotide transport efficiency to leukemia cells by layered double hydroxide
  publication-title: Kagaku to Kogyo
  contributor:
    fullname: Aisawa
– volume: 7
  start-page: 251
  year: 1996
  ident: 10.1016/j.clay.2009.11.032_bib34
  article-title: Hydrotalcite-like anionic clays (layered double hydroxides)
  publication-title: Comprehensive Supramolecular Chemistry
  contributor:
    fullname: Trifiro
– volume: 3
  start-page: 545
  issue: 4
  year: 2006
  ident: 10.1016/j.clay.2009.11.032_bib30
  article-title: Bio-active molecule immobilisation on layered double hydroxides
  publication-title: International Journal of Nanotechnology
  doi: 10.1504/IJNT.2006.011178
  contributor:
    fullname: Ren
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Snippet Layered double hydroxides (LDHs) have been known for many decades as catalyst and ceramic precursors, traps for anionic pollutants, catalysts, and additives...
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SubjectTerms Gene delivery
Layer double hydroxides
Nanoparticles
Title Controlled preparation of layered double hydroxide nanoparticles and their application as gene delivery vehicles
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