Effects of hesperidin consumption on cardiovascular risk biomarkers: a systematic review of animal studies and human randomized clinical trials
The cardioprotective effects of the flavonoid hesperidin, which is present in citrus products, are controversial and unclear. This systematic review was conducted in accordance with the PRISMA 2015 guidelines. To evaluate the current evidence from animal and human clinical studies and thus determine...
Saved in:
Published in | Nutrition reviews Vol. 77; no. 12; pp. 845 - 864 |
---|---|
Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
01.12.2019
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | The cardioprotective effects of the flavonoid hesperidin, which is present in citrus products, are controversial and unclear. This systematic review was conducted in accordance with the PRISMA 2015 guidelines.
To evaluate the current evidence from animal and human clinical studies and thus determine whether the consumption of hesperidin exerts beneficial effects on cardiovascular risk factors.
PICOS (Population, Intervention, Comparison, Outcome, and Study Design) criteria defined the research question. Searches of the PubMed and Cochrane Plus databases were conducted and studies that met the inclusion criteria and were published in English in the last 15 years were included.
The first author, year of publication, study design, characteristics of animals and humans, intervention groups, dose of hesperidin, route of administration, duration of the intervention, cardiovascular risk biomarkers assessed, and results observed were extracted from the included articles.
A total of 12 animal studies and 11 randomized clinical trials met the inclusion criteria. In the animal studies, the glucose, total and LDL cholesterol, and triglyceride levels decreased with chronic flavonoid consumption. In the human studies, endothelial function improved with flavonoid consumption, whereas no conclusive results were observed for the other biomarkers.
Animal studies have revealed that hesperidin and hesperetin consumption reduces glucose levels and various lipid profile parameters. However, a definitive conclusion cannot be drawn from the existing human clinical trials. Further research is needed to confirm whether the findings observed in animal models can also be observed in humans.
Prospero registration number CRD42018088942. |
---|---|
AbstractList | Abstract
Context
The cardioprotective effects of the flavonoid hesperidin, which is present in citrus products, are controversial and unclear. This systematic review was conducted in accordance with the PRISMA 2015 guidelines.
Objective
To evaluate the current evidence from animal and human clinical studies and thus determine whether the consumption of hesperidin exerts beneficial effects on cardiovascular risk factors.
Data sources
PICOS (Population, Intervention, Comparison, Outcome, and Study Design) criteria defined the research question. Searches of the PubMed and Cochrane Plus databases were conducted and studies that met the inclusion criteria and were published in English in the last 15 years were included.
Data extraction
The first author, year of publication, study design, characteristics of animals and humans, intervention groups, dose of hesperidin, route of administration, duration of the intervention, cardiovascular risk biomarkers assessed, and results observed were extracted from the included articles.
Results
A total of 12 animal studies and 11 randomized clinical trials met the inclusion criteria. In the animal studies, the glucose, total and LDL cholesterol, and triglyceride levels decreased with chronic flavonoid consumption. In the human studies, endothelial function improved with flavonoid consumption, whereas no conclusive results were observed for the other biomarkers.
Conclusions
Animal studies have revealed that hesperidin and hesperetin consumption reduces glucose levels and various lipid profile parameters. However, a definitive conclusion cannot be drawn from the existing human clinical trials. Further research is needed to confirm whether the findings observed in animal models can also be observed in humans.
Systematic Review Registration
Prospero registration number CRD42018088942. CONTEXTThe cardioprotective effects of the flavonoid hesperidin, which is present in citrus products, are controversial and unclear. This systematic review was conducted in accordance with the PRISMA 2015 guidelines. OBJECTIVETo evaluate the current evidence from animal and human clinical studies and thus determine whether the consumption of hesperidin exerts beneficial effects on cardiovascular risk factors. DATA SOURCESPICOS (Population, Intervention, Comparison, Outcome, and Study Design) criteria defined the research question. Searches of the PubMed and Cochrane Plus databases were conducted and studies that met the inclusion criteria and were published in English in the last 15 years were included. DATA EXTRACTIONThe first author, year of publication, study design, characteristics of animals and humans, intervention groups, dose of hesperidin, route of administration, duration of the intervention, cardiovascular risk biomarkers assessed, and results observed were extracted from the included articles. RESULTSA total of 12 animal studies and 11 randomized clinical trials met the inclusion criteria. In the animal studies, the glucose, total and LDL cholesterol, and triglyceride levels decreased with chronic flavonoid consumption. In the human studies, endothelial function improved with flavonoid consumption, whereas no conclusive results were observed for the other biomarkers. CONCLUSIONSAnimal studies have revealed that hesperidin and hesperetin consumption reduces glucose levels and various lipid profile parameters. However, a definitive conclusion cannot be drawn from the existing human clinical trials. Further research is needed to confirm whether the findings observed in animal models can also be observed in humans. SYSTEMATIC REVIEW REGISTRATIONProspero registration number CRD42018088942. The cardioprotective effects of the flavonoid hesperidin, which is present in citrus products, are controversial and unclear. This systematic review was conducted in accordance with the PRISMA 2015 guidelines. To evaluate the current evidence from animal and human clinical studies and thus determine whether the consumption of hesperidin exerts beneficial effects on cardiovascular risk factors. PICOS (Population, Intervention, Comparison, Outcome, and Study Design) criteria defined the research question. Searches of the PubMed and Cochrane Plus databases were conducted and studies that met the inclusion criteria and were published in English in the last 15 years were included. The first author, year of publication, study design, characteristics of animals and humans, intervention groups, dose of hesperidin, route of administration, duration of the intervention, cardiovascular risk biomarkers assessed, and results observed were extracted from the included articles. A total of 12 animal studies and 11 randomized clinical trials met the inclusion criteria. In the animal studies, the glucose, total and LDL cholesterol, and triglyceride levels decreased with chronic flavonoid consumption. In the human studies, endothelial function improved with flavonoid consumption, whereas no conclusive results were observed for the other biomarkers. Animal studies have revealed that hesperidin and hesperetin consumption reduces glucose levels and various lipid profile parameters. However, a definitive conclusion cannot be drawn from the existing human clinical trials. Further research is needed to confirm whether the findings observed in animal models can also be observed in humans. Prospero registration number CRD42018088942. |
Author | Valls, R M Pla-Pagà, L Companys, J Calderón-Pérez, L Solà, R Llauradó, E Pedret, A |
Author_xml | – sequence: 1 givenname: L surname: Pla-Pagà fullname: Pla-Pagà, L organization: Hospital Universitari Sant Joan, Reus, Spain – sequence: 2 givenname: J surname: Companys fullname: Companys, J organization: Universitat Rovira i Virgili, Facultat de Medicina i Ciències de la Salut, Functional Nutrition, Oxidation and Cardiovascular Disease Group (NFOC-SALUT), Reus, Spain – sequence: 3 givenname: L surname: Calderón-Pérez fullname: Calderón-Pérez, L organization: Universitat Rovira i Virgili, Facultat de Medicina i Ciències de la Salut, Functional Nutrition, Oxidation and Cardiovascular Disease Group (NFOC-SALUT), Reus, Spain – sequence: 4 givenname: E surname: Llauradó fullname: Llauradó, E organization: Universitat Rovira i Virgili, Facultat de Medicina i Ciències de la Salut, Functional Nutrition, Oxidation and Cardiovascular Disease Group (NFOC-SALUT), Reus, Spain – sequence: 5 givenname: R surname: Solà fullname: Solà, R organization: Hospital Universitari Sant Joan, Reus, Spain – sequence: 6 givenname: R M surname: Valls fullname: Valls, R M organization: Universitat Rovira i Virgili, Facultat de Medicina i Ciències de la Salut, Functional Nutrition, Oxidation and Cardiovascular Disease Group (NFOC-SALUT), Reus, Spain – sequence: 7 givenname: A surname: Pedret fullname: Pedret, A organization: Universitat Rovira i Virgili, Facultat de Medicina i Ciències de la Salut, Functional Nutrition, Oxidation and Cardiovascular Disease Group (NFOC-SALUT), Reus, Spain |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31271436$$D View this record in MEDLINE/PubMed |
BookMark | eNo9kUtLAzEUhYNUtK0u3UqWbkbzmEfjTsQXFNzoeojJHYzOJDU3U7F_wr9sSlW4cG7Cx4Fzz4xMfPBAyAln55wpeeHHFF3KsmGy3iNT3lSyKBeLZkKmjAlV1HUpD8kM8Y0xxoWSB-RQctHwUtZT8n3TdWAS0tDRV8AVRGedpyZ4HIdVcsHTPEZH68Jaoxl7HWl0-E5fXBh0fIeIl1RT_MIEg07O0AhrB59bQ-3doHuKabQOMD8tfR0H7WnMaxjcBiw1vfPOZCrH0D0ekf0uCxz_6pw83948Xd8Xy8e7h-urZWGkFKkAW3HFagud0oYzrjrNZNnxSjHbmMxIAYxXjZI5MNdy-1MKZriFUjaKyTk52_muYvgYAVM7ODTQ99pDGLEVohKiFGqxyGixQ00MiBG6dhVzrvjVctZuO2h3HbS7DjJ_-ms9vgxg_-m_o8sfR3KJgA |
CitedBy_id | crossref_primary_10_1016_j_numecd_2020_11_016 crossref_primary_10_1002_pca_3255 crossref_primary_10_3390_cells12152015 crossref_primary_10_1002_ptr_7092 crossref_primary_10_3389_fnut_2023_1177708 crossref_primary_10_1016_j_dsx_2023_102884 crossref_primary_10_3390_nu14122387 crossref_primary_10_1080_19390211_2022_2107138 crossref_primary_10_1039_D1FO02664J crossref_primary_10_1016_j_clnu_2021_10_009 crossref_primary_10_1002_open_202100223 crossref_primary_10_2174_1573407218666211230140952 crossref_primary_10_3390_nu12051488 crossref_primary_10_1039_D3FO04091G crossref_primary_10_1080_87559129_2023_2228001 crossref_primary_10_1080_10408398_2021_1882382 crossref_primary_10_1017_jns_2023_22 crossref_primary_10_1016_j_cdnut_2023_102055 crossref_primary_10_3390_antiox12030586 crossref_primary_10_3390_nu13020473 crossref_primary_10_1002_mnfr_202001175 crossref_primary_10_1017_S0029665124000156 crossref_primary_10_1007_s00394_020_02279_0 crossref_primary_10_1016_j_foodres_2024_114328 crossref_primary_10_1016_j_bbapap_2023_140898 crossref_primary_10_1002_ptr_7647 crossref_primary_10_2174_0118715206271514231124111026 crossref_primary_10_1016_j_phymed_2023_154836 crossref_primary_10_3390_ijms24097963 crossref_primary_10_1016_j_jff_2021_104646 |
Cites_doi | 10.1016/j.clnu.2014.12.016 10.1016/j.nutres.2010.09.006 10.1021/jf0723007 10.1080/13510002.2017.1344013 10.1002/ptr.5670 10.1080/10408398.2014.906382 10.1021/jf052263o 10.1142/S0192415X18500398 10.3945/ajcn.114.104364 10.1017/S0007114509993679 10.1016/j.etp.2010.10.012 10.1111/j.1440-1681.2008.04939.x 10.1089/ars.2012.4581 10.1016/j.fct.2018.01.022 10.1016/j.vph.2012.02.007 10.1007/s10787-017-0326-3 10.1093/jn/134.10.2499 10.1021/jf100752j 10.1271/bbb.90576 10.1016/j.biopha.2017.10.102 10.1017/S0007114515002950 10.3945/ajcn.111.031088 10.1016/j.atherosclerosis.2006.10.011 10.1186/s12967-018-1448-0 10.1093/ajcn/78.1.57 10.1016/j.maturitas.2010.07.009 10.1016/j.biotechadv.2017.12.001 10.3945/jn.110.124735 10.1039/C4FO00993B 10.1079/BJN20041286 10.1093/ajcn/69.1.30 10.1210/jc.2010-2879 10.1021/jf1044475 10.1093/ajcn/76.6.1222 10.1002/ptr.3724 10.1136/bmj.319.7205.312 10.1007/s00210-004-0994-6 10.3945/ajcn.116.136960 10.1039/C5FO01541C 10.1039/c3fo60030k 10.3945/ajcn.110.004945 10.1016/j.fitote.2013.11.003 10.1016/j.biopha.2017.03.102 10.1093/eurheartj/ehw272 10.3945/ajcn.114.088518 10.3945/jn.115.213660 10.1021/jf3032556 10.1016/j.jdiacomp.2012.06.001 10.1016/j.biocel.2005.12.002 10.1254/jphs.11097FP 10.1371/journal.pone.0128132 |
ContentType | Journal Article |
Copyright | The Author(s) 2019. Published by Oxford University Press on behalf of the International Life Sciences Institute. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. |
Copyright_xml | – notice: The Author(s) 2019. Published by Oxford University Press on behalf of the International Life Sciences Institute. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
DOI | 10.1093/nutrit/nuz036 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
DatabaseTitleList | CrossRef MEDLINE - Academic MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Economics Diet & Clinical Nutrition |
EISSN | 1753-4887 |
EndPage | 864 |
ExternalDocumentID | 10_1093_nutrit_nuz036 31271436 |
Genre | Meta-Analysis Research Support, Non-U.S. Gov't Systematic Review Journal Article |
GroupedDBID | --- -ET -~X 0R~ 123 1OC 29N 36B 4.4 48X 52M 53G 5RE 5WD 6PF 85S AABZA AACZT AAHBH AAMDB AAMVS AAOGV AAPQZ AAPXW AARHZ AASNB AAUAY AAUQX AAVAP AAWTL ABEUO ABIXL ABJNI ABNHQ ABOCM ABPTD ABQLI ABSAR ABWST ABXVV ACGFO ACGFS ACGOD ACUFI ACUTJ ADBBV ADEZT ADGZP ADHKW ADHZD ADIPN ADJQC ADQBN ADRIX ADRTK ADUKH ADVEK ADYVW AEGPL AEGXH AEJOX AEKSI AEMDU AENEX AENZO AEPUE AETBJ AEWNT AFFZL AFIYH AFOFC AFRAH AFXEN AGINJ AGQXC AGSYK AHMBA AIAGR AJEEA AKWXX ALIPV ALMA_UNASSIGNED_HOLDINGS ALUQC APIBT ATGXG AVWKF AXUDD BAFTC BAYMD BCRHZ BEYMZ BHONS BKOMP BTRTY BVRKM BY8 C45 CDBKE CGR CS3 CUY CVF DAKXR DCZOG DILTD DPXWK DU5 EBS ECM EHX EIF EMOBN ESX F5P FLUFQ FOEOM FOTVD FQBLK G-S GAUVT GJXCC H13 HAR HZ~ IH2 J21 KBUDW KOP KSI KSN L7B ML0 N9A NOMLY NOYVH NPM O9- OAWHX OCZFY ODMLO OIG OJQWA OJZSN OPAEJ OVD OWPYF P-O P2P PAFKI PEELM Q5Y RIG ROL ROX ROZ RUSNO RWL RXO RXW SDH TAE TEORI TJX TMA TOX UCV UIG V8K WH7 WQ9 Y6R YAYTL YKOAZ YOC YROCO YXANX ZCA ~KM AAYXX CITATION 7X8 |
ID | FETCH-LOGICAL-c332t-ed51906def9ac1019fa034f1590d7cc3332e0157932931a3c333420c1de437903 |
ISSN | 0029-6643 |
IngestDate | Thu Aug 15 23:46:43 EDT 2024 Thu Sep 12 19:17:52 EDT 2024 Sat Sep 28 08:36:25 EDT 2024 |
IsDoiOpenAccess | false |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 12 |
Keywords | cardiovascular risk biomarkers citrus flavonoids glucose hesperetin lipid profile hesperidin |
Language | English |
License | The Author(s) 2019. Published by Oxford University Press on behalf of the International Life Sciences Institute. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c332t-ed51906def9ac1019fa034f1590d7cc3332e0157932931a3c333420c1de437903 |
Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Undefined-3 |
OpenAccessLink | https://watermark.silverchair.com/nuz036.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAskwggLFBgkqhkiG9w0BBwagggK2MIICsgIBADCCAqsGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMbtapHrnJhSDrBvgxAgEQgIICfLXPGywsiYXIrY1BSKjm23I79Q3_suBrrvZnOfqth0IHKN_bXFXCvXUMMe_QdkFMPdq5bOXcEtYASALfS-UT49iraebwsBBLwYt9cebCeUGv93mjaWO81-enriOh7hg7AqbTmYF1NqqxMR0bqtaT23AbKZ-wFr3Bo4cyVCXXipaJaCXYq28V5AngWK4Sn1n8dcMDXH5dTSRR4W5fhP9-FcCq9Zd8nK8X6QaiLmxAJlGYdSqIPzjUwBR6D5kEYHwfa-OUn-rWw9C9t872RO0tqlDOoAQwmp5Iy9Qem8M0eB-TE3u2lMOopprU7EtmC8V7fnLUu9NzSQ3flkleMwq_UPWZLLkbFjdeWCvExCQpsT12QDiIvcytNGIorJyn4qEdWpFZ5ywtEStPqryLVr8g5zZ3CDN_FXyjhqZdXa7FlqENpqPHM-JHI_vLiH_Pu2d_PhOMy4gl-Gu6_rR5p4HGEBQZ12TkC_KWtigdsS2rUUe5p3GPpXd4wWWPf7exVxhdgT6I-ejM9dWhzBHinNeXhbJqtaMWY79_61ERKH9esepl0S7b_S3QiH117SF2m6o-PU8-8BpRQq4D8dKT5jBM4f8mfWUvvj5Uxy9-NLZDQRVzo9lEISA3HofVMYK-OUs82qBmkS321-jNkf4SxVVr9Hjw-QHGuGRG5VEvk0Xtzp8exPNQNKiOUeZXI1gqYN43fvvErT7E-JcGpsP0eEiicEbJkPt6YvKE-ALGo0srag03R2S3T8mxoW4JcST8fxU5CqtW1OQ52_25PYzOg67PbJGm6R-HW9Q8E6p45pzqLcc5tSOhKh5VsYMKI9ZDFGTZ7x3q8nhOepuznu3Ucg |
PMID | 31271436 |
PQID | 2252242988 |
PQPubID | 23479 |
PageCount | 20 |
ParticipantIDs | proquest_miscellaneous_2252242988 crossref_primary_10_1093_nutrit_nuz036 pubmed_primary_31271436 |
PublicationCentury | 2000 |
PublicationDate | 2019-12-01 20191201 |
PublicationDateYYYYMMDD | 2019-12-01 |
PublicationDate_xml | – month: 12 year: 2019 text: 2019-12-01 day: 01 |
PublicationDecade | 2010 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | Nutrition reviews |
PublicationTitleAlternate | Nutr Rev |
PublicationYear | 2019 |
References | Demonty (2019120308504367400_nuz036-B34) 2010; 140 McKee (2019120308504367400_nuz036-B48) 1999; 319 Soldati (2019120308504367400_nuz036-B3) 2018; 16 Dauchet (2019120308504367400_nuz036-B18) 2004; 92 Santhakumar (2019120308504367400_nuz036-B4) 2018; 113 USDA Economic Research Service (2019120308504367400_nuz036-B7) 2018 Del Rio (2019120308504367400_nuz036-B2) 2013; 18 Andersson (2019120308504367400_nuz036-B56) 2002; 76 Selvaraj (2019120308504367400_nuz036-B22) 2012; 64 Rizza (2019120308504367400_nuz036-B11) 2011; 96 Jayaraman (2019120308504367400_nuz036-B45) 2018; 97 Bredsdorff (2019120308504367400_nuz036-B10) 2010; 103 Brown (2019120308504367400_nuz036-B58) 1999; 69 Mahmoud (2019120308504367400_nuz036-B26) 2012; 26 Adefegha (2019120308504367400_nuz036-B54) 2017; 22 World Health Organization (2019120308504367400_nuz036-B1) 2018 Kumar (2019120308504367400_nuz036-B30) 2012; 57 Yamamoto (2019120308504367400_nuz036-B32) 2013; 4 Ferreira (2019120308504367400_nuz036-B15) 2016; 7 Johnsen (2019120308504367400_nuz036-B17) 2003; 78 Rafiq (2019120308504367400_nuz036-B9) 2018 Iskender (2019120308504367400_nuz036-B24) 2017; 90 Jia (2019120308504367400_nuz036-B31) 2015; 6 Kean (2019120308504367400_nuz036-B38) 2015; 101 Dobiaš (2019120308504367400_nuz036-B25) 2016; 30 Chiou (2019120308504367400_nuz036-B12) 2008; 35 Wunpathe (2019120308504367400_nuz036-B51) 2018; 46 Constans (2019120308504367400_nuz036-B35) 2015; 34 Buscemi (2019120308504367400_nuz036-B36) 2012; 95 Moher (2019120308504367400_nuz036-B23) 2009; 6 Schar (2019120308504367400_nuz036-B37) 2015; 101 Actis-Goretta (2019120308504367400_nuz036-B50) 2006; 54 Ikemura (2019120308504367400_nuz036-B14) 2012; 26 Li (2019120308504367400_nuz036-B6) 2017; 57 Orallo (2019120308504367400_nuz036-B53) 2004; 370 Cesar (2019120308504367400_nuz036-B41) 2010; 30 Jin (2019120308504367400_nuz036-B13) 2007; 194 Nabavi (2019120308504367400_nuz036-B5) 2017; 36 Brüll (2019120308504367400_nuz036-B49) 2015; 114 Akiyama (2019120308504367400_nuz036-B27) 2009; 73 Jung (2019120308504367400_nuz036-B28) 2006; 38 Morand (2019120308504367400_nuz036-B42) 2011; 93 Vogiatzoglou (2019120308504367400_nuz036-B8) 2015; 10 Carballo-Villalobos (2019120308504367400_nuz036-B55) 2017; 25 Lin (2019120308504367400_nuz036-B46) 2011; 59 Constantin (2019120308504367400_nuz036-B44) 2014; 92 Asgary (2019120308504367400_nuz036-B19) 2013; 9 Shen (2019120308504367400_nuz036-B43) 2012; 60 Vargova (2019120308504367400_nuz036-B21) 2016; 4 Liu (2019120308504367400_nuz036-B52) 2008; 56 Potter (2019120308504367400_nuz036-B20) 2011; 10:96 Wang (2019120308504367400_nuz036-B16) 2011; 117 Catapano (2019120308504367400_nuz036-B47) 2016; 37 Vallejo (2019120308504367400_nuz036-B57) 2010; 58 Rangel-Huerta (2019120308504367400_nuz036-B39) 2015; 145 Aptekmann (2019120308504367400_nuz036-B40) 2010; 67 Jung (2019120308504367400_nuz036-B29) 2004; 134 Salden (2019120308504367400_nuz036-B33) 2016; 104 |
References_xml | – volume: 34 start-page: 1093 year: 2015 ident: 2019120308504367400_nuz036-B35 article-title: Marked antioxidant effect of orange juice intake and its phytomicronutrients in a preliminary randomized cross-over trial on mild hypercholesterolemic men publication-title: Clin Nutr doi: 10.1016/j.clnu.2014.12.016 contributor: fullname: Constans – volume: 6 year: 2009 ident: 2019120308504367400_nuz036-B23 article-title: PRISMA 2009 Flow Diagram publication-title: Prism Statement contributor: fullname: Moher – volume: 30 start-page: 689 year: 2010 ident: 2019120308504367400_nuz036-B41 article-title: Orange juice decreases low-density lipoprotein cholesterol in hypercholesterolemic subjects and improves lipid transfer to high-density lipoprotein in normal and hypercholesterolemic subjects publication-title: Nutr Res doi: 10.1016/j.nutres.2010.09.006 contributor: fullname: Cesar – volume: 56 start-page: 824 year: 2008 ident: 2019120308504367400_nuz036-B52 article-title: Distinct effects of naringenin and hesperetin on nitric oxide production from endothelial cells publication-title: J Agric Food Chem. doi: 10.1021/jf0723007 contributor: fullname: Liu – volume: 22 start-page: 563 year: 2017 ident: 2019120308504367400_nuz036-B54 article-title: Hesperidin attenuates inflammation and oxidative damage in pleural exudates and liver of rat model of pleurisy publication-title: Redox Rep doi: 10.1080/13510002.2017.1344013 contributor: fullname: Adefegha – volume: 30 start-page: 1665 year: 2016 ident: 2019120308504367400_nuz036-B25 article-title: Long-term treatment with hesperidin improves endothelium-dependent vasodilation in femoral artery of spontaneously hypertensive rats: the involvement of NO-synthase and Kv channels publication-title: Phytother Res. doi: 10.1002/ptr.5670 contributor: fullname: Dobiaš – volume: 57 start-page: 613 year: 2017 ident: 2019120308504367400_nuz036-B6 article-title: Health-promoting effects of the citrus flavanone hesperidin publication-title: Crit Rev Food Sci Nutr. doi: 10.1080/10408398.2014.906382 contributor: fullname: Li – volume: 54 start-page: 229 year: 2006 ident: 2019120308504367400_nuz036-B50 article-title: Inhibition of angiotensin converting enzyme activity by flavanol-rich foods publication-title: J Agric Food Chem. doi: 10.1021/jf052263o contributor: fullname: Actis-Goretta – volume: 46 start-page: 1 year: 2018 ident: 2019120308504367400_nuz036-B51 article-title: Hesperidin suppresses renin-angiotensin system mediated NOX2 over-expression and sympathoexcitation in 2K-1C hypertensive rats publication-title: Am J Chin Med doi: 10.1142/S0192415X18500398 contributor: fullname: Wunpathe – volume: 101 start-page: 931 year: 2015 ident: 2019120308504367400_nuz036-B37 article-title: Orange juice-derived flavanone and phenolic metabolites do not acutely affect cardiovascular risk biomarkers: a randomized, placebo-controlled, crossover trial in men at moderate risk of cardiovascular disease publication-title: Am J Clin Nutr doi: 10.3945/ajcn.114.104364 contributor: fullname: Schar – volume: 103 start-page: 1602 year: 2010 ident: 2019120308504367400_nuz036-B10 article-title: Absorption, conjugation and excretion of the flavanones, naringenin and hesperetin from alpha-rhamnosidase-treated orange juice in human subjects publication-title: Br J Nutr. doi: 10.1017/S0007114509993679 contributor: fullname: Bredsdorff – volume: 64 start-page: 449 year: 2012 ident: 2019120308504367400_nuz036-B22 article-title: Efficacy of hesperidin on plasma, heart and liver tissue lipids in rats subjected to isoproterenol-induced cardiotoxicity publication-title: Exp Toxicol Pathol doi: 10.1016/j.etp.2010.10.012 contributor: fullname: Selvaraj – volume: 35 start-page: 938 year: 2008 ident: 2019120308504367400_nuz036-B12 article-title: Effects of hesperidin on cyclic strain-induced endothelin-1 release in human umbilical vein endothelial cells publication-title: Clin Exp Pharmacol Physiol. doi: 10.1111/j.1440-1681.2008.04939.x contributor: fullname: Chiou – volume: 18 start-page: 1818 year: 2013 ident: 2019120308504367400_nuz036-B2 article-title: Dietary (poly)phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases publication-title: Antioxid Redox Signal doi: 10.1089/ars.2012.4581 contributor: fullname: Del Rio – volume: 113 start-page: 49 year: 2018 ident: 2019120308504367400_nuz036-B4 article-title: Dietary polyphenols: structures, bioavailability and protective effects against atherosclerosis publication-title: . Food Chem Toxicol doi: 10.1016/j.fct.2018.01.022 contributor: fullname: Santhakumar – volume: 57 start-page: 201 year: 2012 ident: 2019120308504367400_nuz036-B30 article-title: Hesperetin ameliorates hyperglycemia induced retinal vasculopathy via anti-angiogenic effects in experimental diabetic rats publication-title: Vascul Pharmacol doi: 10.1016/j.vph.2012.02.007 contributor: fullname: Kumar – volume: 25 start-page: 259 year: 2017 ident: 2019120308504367400_nuz036-B55 article-title: Pro-inflammatory cytokines involvement in the hesperidin antihyperalgesic effects at peripheral and central levels in a neuropathic pain model publication-title: Inflammopharmacology. doi: 10.1007/s10787-017-0326-3 contributor: fullname: Carballo-Villalobos – volume: 4 start-page: 228 year: 2016 ident: 2019120308504367400_nuz036-B21 article-title: Bioavailability in humans of the flavanones hesperidin and narirutin after the ingestion of two doses of orange juice publication-title: J Agric Food Chem contributor: fullname: Vargova – volume: 134 start-page: 2499 year: 2004 ident: 2019120308504367400_nuz036-B29 article-title: The hypoglycemic effects of hesperidin and naringin are partly mediated by hepatic glucose-regulating enzymes in C57BL/KsJ-db/db mice publication-title: J Nutr. doi: 10.1093/jn/134.10.2499 contributor: fullname: Jung – volume: 58 start-page: 6516 year: 2010 ident: 2019120308504367400_nuz036-B57 article-title: Concentration and solubility of flavanones in orange beverages affect their bioavailability in humans publication-title: J Agric Food Chem. doi: 10.1021/jf100752j contributor: fullname: Vallejo – volume: 73 start-page: 2779 year: 2009 ident: 2019120308504367400_nuz036-B27 article-title: Hypoglycemic and hypolipidemic effects of hesperidin and cyclodextrin-clathrated hesperetin in Goto-Kakizaki rats with type 2 diabetes publication-title: Biosci Biotechnol Biochem doi: 10.1271/bbb.90576 contributor: fullname: Akiyama – volume: 97 start-page: 98 year: 2018 ident: 2019120308504367400_nuz036-B45 article-title: Antihyperglycemic effect of hesperetin, a citrus flavonoid, extenuates hyperglycemia and exploring the potential role in antioxidant and antihyperlipidemic in streptozotocin-induced diabetic rats publication-title: Biomed Pharmacother doi: 10.1016/j.biopha.2017.10.102 contributor: fullname: Jayaraman – volume: 114 start-page: 1263 year: 2015 ident: 2019120308504367400_nuz036-B49 article-title: Effects of a quercetin-rich onion skin extract on 24 h ambulatory blood pressure and endothelial function in overweight-to-obese patients with (pre-)hypertension: a randomised double-blinded placebo-controlled cross-over trial publication-title: Br J Nutr. doi: 10.1017/S0007114515002950 contributor: fullname: Brüll – volume: 95 start-page: 1089 year: 2012 ident: 2019120308504367400_nuz036-B36 article-title: Effects of red orange juice intake on endothelial function and inflammatory markers in adult subjects with increased cardiovascular risk publication-title: Am J Clin Nutr. doi: 10.3945/ajcn.111.031088 contributor: fullname: Buscemi – volume: 194 start-page: 144 year: 2007 ident: 2019120308504367400_nuz036-B13 article-title: Antiplatelet activity of hesperetin, a bioflavonoid, is mainly mediated by inhibition of PLC-γ2 phosphorylation and cyclooxygenase-1 activity publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2006.10.011 contributor: fullname: Jin – volume: 16 start-page: 75. year: 2018 ident: 2019120308504367400_nuz036-B3 article-title: The influence of diet on anti-cancer immune responsiveness publication-title: J Transl Med. doi: 10.1186/s12967-018-1448-0 contributor: fullname: Soldati – volume: 10:96 year: 2011 ident: 2019120308504367400_nuz036-B20 article-title: Drinking carrot juice increases total antioxidant status and decreases lipid peroxidation in adults publication-title: Nutr J contributor: fullname: Potter – volume: 78 start-page: 57 year: 2003 ident: 2019120308504367400_nuz036-B17 article-title: Intake of fruit and vegetables and the risk of ischemic stroke in a cohort of Danish men and women publication-title: Am J Clin Nutr. doi: 10.1093/ajcn/78.1.57 contributor: fullname: Johnsen – year: 2018 ident: 2019120308504367400_nuz036-B1 contributor: fullname: World Health Organization – volume: 67 start-page: 343 year: 2010 ident: 2019120308504367400_nuz036-B40 article-title: Orange juice improved lipid profile and blood lactate of overweight middle-aged women subjected to aerobic training publication-title: Maturitas doi: 10.1016/j.maturitas.2010.07.009 contributor: fullname: Aptekmann – volume: 36 start-page: 1768 year: 2017 ident: 2019120308504367400_nuz036-B5 article-title: Regulation of autophagy by polyphenols: paving the road for treatment of neurodegeneration publication-title: Biotechnol Adv. doi: 10.1016/j.biotechadv.2017.12.001 contributor: fullname: Nabavi – volume: 140 start-page: 1615 year: 2010 ident: 2019120308504367400_nuz036-B34 article-title: The citrus flavonoids hesperidin and naringin do not affect serum cholesterol in moderately hypercholesterolemic men and women publication-title: J Nutr doi: 10.3945/jn.110.124735 contributor: fullname: Demonty – volume: 6 start-page: 878 year: 2015 ident: 2019120308504367400_nuz036-B31 article-title: Hypoglycemic and hypolipidemic effects of neohesperidin derived from Citrus aurantium L. in diabetic KK-A(y) mice publication-title: Food Funct. doi: 10.1039/C4FO00993B contributor: fullname: Jia – volume: 92 start-page: 963 year: 2004 ident: 2019120308504367400_nuz036-B18 article-title: Frequency of fruit and vegetable consumption and coronary heart disease in France and Northern Ireland: the PRIME study publication-title: Br J Nutr. doi: 10.1079/BJN20041286 contributor: fullname: Dauchet – volume: 69 start-page: 30 year: 1999 ident: 2019120308504367400_nuz036-B58 article-title: Cholesterol-lowering effects of dietary fiber: a meta-analysis publication-title: Am J Clin Nutr. doi: 10.1093/ajcn/69.1.30 contributor: fullname: Brown – volume: 96 start-page: 782 year: 2011 ident: 2019120308504367400_nuz036-B11 article-title: Citrus polyphenol hesperidin stimulates production of nitric oxide in endothelial cells while improving endothelial function and reducing inflammatory markers in patients with metabolic syndrome publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2010-2879 contributor: fullname: Rizza – volume: 59 start-page: 4496 year: 2011 ident: 2019120308504367400_nuz036-B46 article-title: Molecular structures of citrus flavonoids determine their effects on lipid metabolism in HepG2 cells by primarily suppressing apoB secretion publication-title: J Agric Food Chem. doi: 10.1021/jf1044475 contributor: fullname: Lin – start-page: 351 volume-title: J Saudi Soc Agric Sci year: 2018 ident: 2019120308504367400_nuz036-B9 article-title: Citrus peel as a source of functional ingredient: a review contributor: fullname: Rafiq – volume: 76 start-page: 1222 year: 2002 ident: 2019120308504367400_nuz036-B56 article-title: Fatty acid composition of skeletal muscle reflects dietary fat composition in humans publication-title: Am J Clin Nutr. doi: 10.1093/ajcn/76.6.1222 contributor: fullname: Andersson – volume: 26 start-page: 1272 year: 2012 ident: 2019120308504367400_nuz036-B14 article-title: Preventive effects of hesperidin, glucosyl hesperidin and naringin on hypertension and cerebral thrombosis in stroke-prone spontaneously hypertensive rats publication-title: Phytother Res. doi: 10.1002/ptr.3724 contributor: fullname: Ikemura – volume: 319 start-page: 312 year: 1999 ident: 2019120308504367400_nuz036-B48 article-title: Methods in health services research. Interpreting the evidence: choosing between randomised and non-randomised studies publication-title: BMJ. doi: 10.1136/bmj.319.7205.312 contributor: fullname: McKee – volume: 370 start-page: 452 year: 2004 ident: 2019120308504367400_nuz036-B53 article-title: Comparative study of the vasorelaxant activity, superoxide-scavenging ability and cyclic nucleotide phosphodiesterase-inhibitory effects of hesperetin and hesperidin publication-title: Naunyn Schmiedebergs Arch Pharmacol. doi: 10.1007/s00210-004-0994-6 contributor: fullname: Orallo – volume: 104 start-page: 1523 year: 2016 ident: 2019120308504367400_nuz036-B33 article-title: Randomized clinical trial on the efficacy of hesperidin 2S on validated cardiovascular biomarkers in healthy overweight individuals publication-title: Am J Clin Nutr doi: 10.3945/ajcn.116.136960 contributor: fullname: Salden – volume: 7 start-page: 2675 year: 2016 ident: 2019120308504367400_nuz036-B15 article-title: Citrus flavanones prevent systemic inflammation and ameliorate oxidative stress in C57BL/6J mice fed high-fat diet publication-title: Food Funct. doi: 10.1039/C5FO01541C contributor: fullname: Ferreira – year: 2018 ident: 2019120308504367400_nuz036-B7 contributor: fullname: USDA Economic Research Service – volume: 4 start-page: 1346. year: 2013 ident: 2019120308504367400_nuz036-B32 article-title: Hesperidin metabolite hesperetin-7-O-glucuronide, but not hesperetin-3′-O-glucuronide, exerts hypotensive, vasodilatory, and anti-inflammatory activities publication-title: Food Funct. doi: 10.1039/c3fo60030k contributor: fullname: Yamamoto – volume: 93 start-page: :73 year: 2011 ident: 2019120308504367400_nuz036-B42 article-title: Hesperidin contributes to the vascular protective effects of orange juice: a randomized crossover study in healthy volunteers publication-title: Am J Clin Nutr doi: 10.3945/ajcn.110.004945 contributor: fullname: Morand – volume: 92 start-page: 148 year: 2014 ident: 2019120308504367400_nuz036-B44 article-title: Molecular mechanisms of citrus flavanones on hepatic gluconeogenesis publication-title: Fitoterapia doi: 10.1016/j.fitote.2013.11.003 contributor: fullname: Constantin – volume: 90 start-page: 500 year: 2017 ident: 2019120308504367400_nuz036-B24 article-title: The effect of hesperidin and quercetin on oxidative stress, NF-κB and SIRT1 levels in a STZ-induced experimental diabetes model publication-title: Biomed Pharmacother doi: 10.1016/j.biopha.2017.03.102 contributor: fullname: Iskender – volume: 37 start-page: 2999 year: 2016 ident: 2019120308504367400_nuz036-B47 article-title: 2016 ESC/EAS guidelines for the management of dyslipidaemias publication-title: Eur Heart J. doi: 10.1093/eurheartj/ehw272 contributor: fullname: Catapano – volume: 101 start-page: 506 year: 2015 ident: 2019120308504367400_nuz036-B38 article-title: Chronic consumption of flavanone-rich orange juice is associated with cognitive benefits: an 8-wk, randomized, double-blind, placebo-controlled trial in healthy older adults publication-title: Am J Clin Nutr doi: 10.3945/ajcn.114.088518 contributor: fullname: Kean – volume: 145 start-page: 1808 year: 2015 ident: 2019120308504367400_nuz036-B39 article-title: Normal or high polyphenol concentration in orange juice affects antioxidant activity, blood pressure, and body weight in obese or overweight adults publication-title: J Nutr. doi: 10.3945/jn.115.213660 contributor: fullname: Rangel-Huerta – volume: 60 start-page: 9609 year: 2012 ident: 2019120308504367400_nuz036-B43 article-title: Inhibitory effects of Citrus flavonoids on starch digestion and antihyperglycemic effects in HepG2 cells publication-title: J Agric Food Chem. doi: 10.1021/jf3032556 contributor: fullname: Shen – volume: 9 start-page: 98 year: 2013 ident: 2019120308504367400_nuz036-B19 article-title: Effects of Citrus sinensis juice on blood pressure publication-title: ARYA Atheroscler. contributor: fullname: Asgary – volume: 26 start-page: 483 year: 2012 ident: 2019120308504367400_nuz036-B26 article-title: Hesperidin and naringin attenuate hyperglycemia-mediated oxidative stress and proinflammatory cytokine production in high fat fed/streptozotocin-induced type 2 diabetic rats publication-title: J Diabetes Complications doi: 10.1016/j.jdiacomp.2012.06.001 contributor: fullname: Mahmoud – volume: 38 start-page: 1134 year: 2006 ident: 2019120308504367400_nuz036-B28 article-title: Effect of citrus flavonoids on lipid metabolism and glucose-regulating enzyme mRNA levels in type-2 diabetic mice publication-title: Int J Biochem Cell Biol. doi: 10.1016/j.biocel.2005.12.002 contributor: fullname: Jung – volume: 117 start-page: 129 year: 2011 ident: 2019120308504367400_nuz036-B16 article-title: Effects of hesperidin on the progression of hypercholesterolemia and fatty liver induced by high-cholesterol diet in rats publication-title: J Pharmacol Sci. doi: 10.1254/jphs.11097FP contributor: fullname: Wang – volume: 10 year: 2015 ident: 2019120308504367400_nuz036-B8 article-title: Flavonoid intake in European adults (18 to 64 years publication-title: PLoS One doi: 10.1371/journal.pone.0128132 contributor: fullname: Vogiatzoglou |
SSID | ssj0001293 |
Score | 2.4841766 |
SecondaryResourceType | review_article |
Snippet | The cardioprotective effects of the flavonoid hesperidin, which is present in citrus products, are controversial and unclear. This systematic review was... Abstract Context The cardioprotective effects of the flavonoid hesperidin, which is present in citrus products, are controversial and unclear. This systematic... CONTEXTThe cardioprotective effects of the flavonoid hesperidin, which is present in citrus products, are controversial and unclear. This systematic review was... |
SourceID | proquest crossref pubmed |
SourceType | Aggregation Database Index Database |
StartPage | 845 |
SubjectTerms | Animals Biomarkers Cardiovascular Diseases Cardiovascular System - drug effects Hesperidin - pharmacology Humans Randomized Controlled Trials as Topic Risk Factors |
Title | Effects of hesperidin consumption on cardiovascular risk biomarkers: a systematic review of animal studies and human randomized clinical trials |
URI | https://www.ncbi.nlm.nih.gov/pubmed/31271436 https://search.proquest.com/docview/2252242988 |
Volume | 77 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLbKkGAv0xi3joGMhPZm5sRpk_AGY2hCMPrQSX2LHNsdldp0atKX_gl-wv7qjn2cSweTACmK0lxsNefTOZ_j8x0T8m6QGA3EQrJkKjmLVG6YFEqwoUzNUKvIBE4U9v1ieH4ZfZ0MJr3eTSdraV3l79Xmj7qS_7EqnAO7WpXsP1i2aRROwDHYF_ZgYdj_lY3P2mSMn8aW_J5pl1ZuVZXoCmBT2xmnLpfciu5tXs6qRLHz3XrOTssii9nCqUlcpqGbZcAV_SC86eVitgGu2ggr3eofZZfqXtR1_n2TDXkfzSUbySs3Rc9b4YPTijjnVG5NV51Ku5C4vfuTKNgIZ_ZX-OG7efLbXK5XgFZ3Vyuw8J8zgrSTGmLQBcMAioFbibs-2i_14rEYdjxugtUof4sEWCWrcH_VHWw4Vlrp4OJ64YAhgtCuAn-nIjfGeH_pAXkYxunA5oyOf0yaUG_Jki_cCv2dYG8n2NcueVQ_vc157hnIOEIz3id7fiRCPyKsnpCeKQ5I__PMVPSY-nKxc9pY8YA8rkXs5VPyy0OPLqe0hR7tQI_Ctg09aqFHW-h9oJK2wKOIEtsgAo964MFPTR3waAs8WgOPIvCekcsvZ-PTc-bX9mBKiLBiRsPQgQ-1maZSQVhIwVWIaArkmutYwT0iNMBUIXrAKw6s-xAiCrkKtLEVNLl4TnaKZWFeEhrxHFh-oGWcykhEiUxMmsdBanLBuVSqT47rt59dYwmXDFMvRIYWy9BiffK2tk0GTtbOnMnCLNdlBkEPqG6YJkmfvECjNU3VRj6898orstsi_YjsVKu1eQ1UtsrfODjdAqY7pgA |
link.rule.ids | 315,786,790,27955,27956 |
linkProvider | Oxford University Press |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Effects+of+hesperidin+consumption+on+cardiovascular+risk+biomarkers%3A+a+systematic+review+of+animal+studies+and+human+randomized+clinical+trials&rft.jtitle=Nutrition+reviews&rft.au=Pla-Pag%C3%A0%2C+L&rft.au=Companys%2C+J&rft.au=Calder%C3%B3n-P%C3%A9rez%2C+L&rft.au=Llaurad%C3%B3%2C+E&rft.date=2019-12-01&rft.eissn=1753-4887&rft.volume=77&rft.issue=12&rft.spage=845&rft_id=info:doi/10.1093%2Fnutrit%2Fnuz036&rft_id=info%3Apmid%2F31271436&rft.externalDocID=31271436 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0029-6643&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0029-6643&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0029-6643&client=summon |