Regional locus coeruleus degeneration is uncoupled from noradrenergic terminal loss in Parkinson’s disease

• Published in: Brain (London, England : 1878) Vol. 144; no. 9; pp. 2732 - 2744
• Main Authors: Doppler, Christopher E J, Kinnerup, Martin B, Brune, Corinna, Farrher, Ezequiel, Betts, Matthew, Fedorova, Tatyana D, Schaldemose, Jeppe L, Knudsen, Karoline, Ismail, Rola, Seger, Aline D, Hansen, Allan K, Stær, Kristian, Fink, Gereon R, Brooks, David J, Nahimi, Adjmal, Borghammer, Per, Sommerauer, Michael
• Format: Journal Article
• Language: English
• Published: England 22.10.2021
• Subjects: Aged; Aged, 80 and over; Female; Humans; Locus Coeruleus - diagnostic imaging; Locus Coeruleus - metabolism; Magnetic Resonance Imaging - methods; Male; Middle Aged; Multimodal Imaging - methods; Norepinephrine Plasma Membrane Transport Proteins - metabolism; Parkinson Disease - diagnostic imaging; Parkinson Disease - metabolism; Positron-Emission Tomography - methods; noradrenaline; positron emission tomography; Parkinson’s disease; neuromelanin; MeNER

Previous studies have reported substantial involvement of the noradrenergic system in Parkinson’s disease. Neuromelanin-sensitive MRI sequences and PET tracers have become available to visualize the cell bodies in the locus coeruleus and the density of noradrenergic terminal transporters. Combining...