Proteinases, Their Extracellular Targets, and Inflammatory Signaling

• Published in: Pharmacological reviews Vol. 68; no. 4; pp. 1110 - 1142
• Main Authors: Ramachandran, Rithwik, Altier, Christophe, Oikonomopoulou, Katerina, Hollenberg, Morley D
• Format: Journal Article
• Language: English
• Published: United States 01.10.2016

Given that over 2% of the human genome codes for proteolytic enzymes and their inhibitors, it is not surprising that proteinases serve many physiologic-pathophysiological roles. In this context, we provide an overview of proteolytic mechanisms regulating inflammation, with a focus on cell signaling...