Contribution of Carboxylesterase and Cytochrome P450 to the Bioactivation and Detoxification of Isocarbophos and Its Enantiomers in Human Liver Microsomes - Zhuang, Xiao-Mei; Wei, Xia; Tan, Yan; Xiao, Wei-Bin; Yang, Hai-Ying; Xie, Jian-Wei; Lu, Chuang; Li, Hua (Toxicological sciences, 2014)
Keywords: Acetylcholinesterase - chemistry; Animals; Carboxylesterase - antagonists & inhibitors; Carboxylesterase - metabolism; Cholinesterase Inhibitors - chemistry; Cholinesterase Inhibitors - metabolism; Cholinesterase Inhibitors - pharmacokinetics; Cholinesterase Inhibitors - pharmacology; Cytochrome P-450 Enzyme System - metabolism; Electrophorus; Enzyme Activation; Humans; Inactivation, Metabolic; Insecticides - chemistry; Insecticides - metabolism; Insecticides - pharmacokinetics; Insecticides - pharmacology; Malathion - analogs & derivatives; Malathion - chemistry; Malathion - metabolism; Malathion - pharmacokinetics; Malathion - pharmacology; Microsomes, Liver - drug effects; Microsomes, Liver - enzymology; Microsomes, Liver - metabolism; Molecular Structure; Recombinant Proteins - chemistry; Stereoisomerism; toxicity; enantiomers; isocarbophos oxon; isocarbophos; enzyme kinetics