Radioprotection by Pressor Amidines

In the mouse, radioprotection is not always associated with the effect of hypertensive amidines and related amines. The protection resulting from this group of agents follows the pharmacological reduction of intercellular oxygen tension.

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Published inScience (American Association for the Advancement of Science) Vol. 141; no. 3576; p. 160
Main Authors Rothe, William E., Grenan, Marie M., Wilson, Shirley M.
Format Journal Article
LanguageEnglish
Published United States American Association for the Advancement of Science 12.07.1963
AAAS
Subjects
AET
ALKALOIDS
Amidines
AMINES
Animals
Dosage
EFFICIENCY
Guanidines
MICE
Old Medline
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
OXYGEN
Pharmacology
PRESSURE
Pyridines
QUANTITY RATIO
Radiation dosage
RADIATION DOSES
RADIATION PROTECTION
Radiation-Protective Agents
RADIOLOGY AND NUCLEAR MEDICINE
RADIOSENSITIVITY
TISSUES
VARIATIONS
RADIATION-PROTECTIVE AGENTS
PYRIDINES
AMINES
GUANIDINES
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Abstract In the mouse, radioprotection is not always associated with the effect of hypertensive amidines and related amines. The protection resulting from this group of agents follows the pharmacological reduction of intercellular oxygen tension.
AbstractList In the mouse, radioprotection is not always associated with the effect of hypertensive amidines and related amines. The protection resulting from this group of agents follows the pharmacological reduction of intercellular oxygen tension. oxygen tension of radiosensitive tissues.
Abstract only
BS>Studies were made on the effects of pressor amidines and pharmacologically related amines on the radiosensitivity of mice exposed to about 100 r/min. The results showed that S-ethylisothiuronium is radioprotective when used over a wide dose range and for a considerable period of time. Also, papaverine, a known pharmacological antagonist significantly reduced the protective effect of a massive dose of S-ethylisothiuronium. It is suggested that pressor amidines offer radioprotective activity through a pharmacological mechanism, which leads to a lowered oxygen tension of radiosensitive tissues.
In the mouse, radioprotection is not always associated with the effect of hypertensive amidines and related amines. The protection resulting from this group of agents follows the pharmacological reduction of intercellular oxygen tension.
Author Rothe, William E.
Grenan, Marie M.
Wilson, Shirley M.
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  givenname: Shirley M.
  surname: Wilson
  fullname: Wilson, Shirley M.
BackLink https://www.ncbi.nlm.nih.gov/pubmed/13975357$$D View this record in MEDLINE/PubMed
https://www.osti.gov/biblio/4673559$$D View this record in Osti.gov
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Issue 3576
Keywords RADIATION-PROTECTIVE AGENTS
PYRIDINES
AMINES
GUANIDINES
Language English
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Snippet In the mouse, radioprotection is not always associated with the effect of hypertensive amidines and related amines. The protection resulting from this group of...
Abstract only
BS>Studies were made on the effects of pressor amidines and pharmacologically related amines on the radiosensitivity of mice exposed to about 100 r/min. The...
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StartPage 160
SubjectTerms AET
ALKALOIDS
Amidines
AMINES
Animals
Dosage
EFFICIENCY
Guanidines
MICE
Old Medline
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
OXYGEN
Pharmacology
PRESSURE
Pyridines
QUANTITY RATIO
Radiation dosage
RADIATION DOSES
RADIATION PROTECTION
Radiation-Protective Agents
RADIOLOGY AND NUCLEAR MEDICINE
RADIOSENSITIVITY
TISSUES
VARIATIONS
Title Radioprotection by Pressor Amidines
URI https://www.jstor.org/stable/1710694
https://www.ncbi.nlm.nih.gov/pubmed/13975357
https://search.proquest.com/docview/83239689
https://www.osti.gov/biblio/4673559
Volume 141
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