A randomized placebo-controlled trial of duloxetine in patients with major depressive disorder and associated painful physical symptoms

• Published in: Current medical research and opinion Vol. 27; no. 10; p. 1849
• Main Authors: Gaynor, Paula J, Gopal, Murali, Zheng, Wei, Martinez, James M, Robinson, Michael J, Marangell, Lauren B
• Format: Journal Article
• Language: English
• Published: England 01.10.2011
• Subjects: Adult; Aged; Aged, 80 and over; Antidepressive Agents - administration & dosage; Antidepressive Agents - adverse effects; Depressive Disorder, Major - complications; Depressive Disorder, Major - drug therapy; Double-Blind Method; Duloxetine Hydrochloride; Female; Humans; Male; Middle Aged; Pain - complications; Pain - drug therapy; Remission Induction; Thiophenes - administration & dosage; Thiophenes - adverse effects; Time Factors

Painful physical symptoms are common in patients with major depressive disorder (MDD) and may predict poorer treatment outcomes. Duloxetine has demonstrated efficacy in treating both MDD and certain other painful conditions. This randomized, double-blind clinical trial assessed the effects of duloxe...