SLC6A14 Is a Genetic Modifier of Cystic Fibrosis That Regulates Pseudomonas aeruginosa Attachment to Human Bronchial Epithelial Cells

• Published in: mBio Vol. 8; no. 6
• Main Authors: Di Paola, Michelle, Park, Amber J, Ahmadi, Saumel, Roach, Elyse J, Wu, Yu-Sheng, Struder-Kypke, Michaela, Lam, Joseph S, Bear, Christine E, Khursigara, Cezar M
• Format: Journal Article
• Language: English
• Published: United States 19.12.2017
• Subjects: Amino Acid Transport Systems - deficiency; Amino Acid Transport Systems, Neutral - metabolism; Animals; Arginine - metabolism; Bacterial Adhesion; Cystic Fibrosis - complications; Epithelial Cells - microbiology; Humans; Mice, Knockout; Plasma Membrane Neurotransmitter Transport Proteins - deficiency; Pseudomonas aeruginosa - metabolism; Pseudomonas aeruginosa - physiology; Pseudomonas Infections - physiopathology; bacterial colonization; airway epithelia; cystic fibrosis; l-arginine uptake; SLC6A14; modifier gene; Pseudomonas aeruginosa; CFTR mutation

Cystic fibrosis (CF) is caused by mutations in the gene and is associated with progressive and ultimately fatal infectious lung disease. There can be considerable variability in disease severity among individuals with the same mutations, and recent genome-wide association studies have identified sec...