Spatio-temporal pattern of ocular clusterin mRNA expression in the rd mouse

• Published in: Brain research. Molecular brain research. Vol. 29; no. 1; pp. 172 - 176
• Main Authors: Jomary, C., Ahir, A., Agarwal, N., Neal, M.J., Jones, S.E.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.03.1995; Elsevier
• Subjects: Aging - metabolism; Animals; Animals, Newborn; Autoradiography; Biological and medical sciences; Blotting, Northern; Clusterin; Eye - metabolism; Gene expression; Glycoproteins - genetics; Medical sciences; Mice; Molecular Chaperones; Nerve Tissue Proteins - genetics; Ophthalmology; Photoreceptor degeneration; Rats; Rats, Inbred Strains - genetics; rd Mouse; Retina; Retinal Degeneration - genetics; Retinal Degeneration - metabolism; Retinopathies; RNA, Messenger - metabolism; Time Factors; Tissue Distribution; Retina; Gene expression; Photoreceptor degeneration; rd Mouse; Clusterin; Animal model; Retinopathy; Retinitis pigmentosa; Rodentia; Genetic disease; Proteins; Eye disease; Vertebrata; Mammalia; Mouse; Animal
• ISSN: 0169-328X; 1872-6941
• DOI: 10.1016/0169-328X(94)00252-A

To define the relationship between progressive photoreceptor degeneration and clusterin upregulation, we analysed the spatio-temporal distribution and level of clusterin mRNA in the retinal degeneration ( rd) mouse. Expression was increased in the retinal pigment epithelium and inner retina, but not detected in the photoreceptors. These results indicate that increased clusterin mRNA is not causally involved in apoptotic mechanisms of photoreceptor death but may relate to lipid-recycling or cytoprotective functions.