Lack of predictivity of bone marrow micronucleus test versus testis micronucleus test: comparison with four carcinogens

• Published in: Mutation Research Vol. 292; no. 2; pp. 105 - 111
• Main Authors: Cliet, I., Melcion, C., Cordier, A.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.10.1993; Elsevier
• Subjects: Animals; Biological and medical sciences; Bone Marrow - drug effects; Bone Marrow - ultrastructure; Carcinogens - toxicity; Chemical mutagenesis; Diethylnitrosamine - toxicity; Dimethylhydrazines - toxicity; Dimethylnitrosamine - toxicity; Hepatocytes; Male; Medical sciences; Mice; Micronuclei; Micronucleus Tests; Mouse; Polychromatic erythrocytes; Predictive Value of Tests; Propiolactone - toxicity; Spermatids; Spermatids - drug effects; Spermatids - ultrastructure; Testis - drug effects; Testis - ultrastructure; Toxicology; MNT; Hepatocytes; Mouse; DMN; PCEs; Polychromatic erythrocytes; Micronuclei; 1,1-DMH; Spermatids; DEN; BPL; Performance evaluation; Carcinogen; Vertebrata; Mammalia; Micronucleus test; Mutagenicity testing; Rodentia; Bone marrow; Testicle
• ISSN: 0165-1161; 0027-5107
• DOI: 10.1016/0165-1161(93)90137-O

In vivo somatic chromosome mutation tests are usually carried out using the bone marrow micronucleus test in the mouse. This test is also considered predictive for the study of clastogenic effects in germ cells. However, it has been reported that the sensitivity of the bone marrow micronucleus test...