Evaluating in vivo delivery of riboflavin with coulomb-controlled iontophoresis for corneal collagen cross-linking: a pilot study

• Published in: Investigative ophthalmology & visual science Vol. 55; no. 4; pp. 2731 - 2738
• Main Authors: Arboleda, Alejandro, Kowalczuk, Laura, Savoldelli, Michèle, Klein, Christophe, Ladraa, Sophia, Naud, Marie-Christine, Aguilar, Mariela C, Parel, Jean-Marie, Behar-Cohen, Francine
• Format: Journal Article
• Language: English
• Published: United States 28.04.2014
• Subjects: Animals; Collagen - drug effects; Collagen - metabolism; Cornea - drug effects; Cornea - metabolism; Cornea - pathology; Cross-Linking Reagents; Disease Models, Animal; Drug Delivery Systems; Iontophoresis - methods; Keratoconus - drug therapy; Keratoconus - metabolism; Keratoconus - pathology; Microscopy, Confocal; Photosensitizing Agents - administration & dosage; Pilot Projects; Rats; Rats, Inbred Lew; Riboflavin - administration & dosage; Treatment Outcome; keratoconus; collagen cross-linking; drug delivery; iontophoresis; riboflavin

To evaluate the efficacy of coulomb-controlled iontophoresis (CCI) for delivery of riboflavin prior to corneal collagen cross-linking (CXL). The eyes of 20 8-week-old Lewis rats, subject to epithelium-ON (epi-ON, n = 20 eyes) or epithelium-OFF (epi-OFF, n = 20 eyes) conditions, were used to evaluate...