Sidechain structure-activity relationships of cyclobutane-based small molecule αvβ3 antagonists

• Published in: MedChemComm Vol. 15; no. 1; pp. 3616 - 3624
• Main Authors: Throup, Adam, Zraikat, Manar Saleh, Gordon, Andrew, Jafarinejad Soumehsaraei, Shohreh, Haase, Kathrin D, Patterson, Laurence H, Cooper, Patricia A, Hanlon, Katherine, Loadman, Paul M, Sutherland, Mark, Shnyder, Steven D, Sheldrake, Helen M
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 17.10.2024
• Subjects: Acids; Aspartic acid; Cancer; Carboxylic acids; Cell surface; Cyclobutane; Drug development; Drug discovery; Extracellular matrix; Glycine; In vivo methods and tests; Lead compounds; Molecular structure; Synthesis

The integrin family of cell surface extracellular matrix binding proteins are key to several physiological processes involved in tissue development, as well as cancer proliferation and dissemination. They are therefore attractive targets for drug discovery with cancer and non-cancer applications. We...