In vitro activation of lymphocytes from nonsmall cell cancer patients by interleukin 2 and anti-CD3 antibody

• Published in: Clinical immunology and immunopathology Vol. 50; no. 3; pp. 348 - 363
• Main Authors: Pisani, Richard J., Leibson, Paul J., McKean, David J.
• Format: Journal Article
• Language: English
• Published: San Diego, CA Elsevier Inc 01.03.1989; New York, NY Academic Press; Boston
• Subjects: Aged; Antibodies, Monoclonal - physiology; Antigens, Differentiation, T-Lymphocyte - immunology; Biological and medical sciences; Carcinoma, Non-Small-Cell Lung - immunology; Carcinoma, Non-Small-Cell Lung - pathology; CD3 Complex; Cell Movement; Cells, Cultured; Drug Combinations; Female; Humans; Interleukin-2 - pharmacology; Lung Neoplasms - immunology; Lung Neoplasms - pathology; Lymphocyte Activation; Male; Medical sciences; Middle Aged; Phenotype; Pneumology; Receptors, Antigen, T-Cell - immunology; Recombinant Proteins - pharmacology; T-Lymphocytes, Cytotoxic - classification; T-Lymphocytes, Cytotoxic - pathology; Tumors of the respiratory system and mediastinum; Human; Interleukin 2; Respiratory disease; Tumor; Activation; Monoclonal antibody; In vitro; Lymphocyte; Bronchopulmonary; Non small cell carcinoma

The current interest in adoptive immunotherapy of cancer has stimulated research into novel approaches of activating lymphocytes in vitro. We have studied the effect of anti-CD3 antibody on the in vitro activation of peripheral blood lymphocytes and tumor infiltrating lymphocytes (TIL) taken from pa...