In vitro activation of lymphocytes from nonsmall cell cancer patients by interleukin 2 and anti-CD3 antibody
The current interest in adoptive immunotherapy of cancer has stimulated research into novel approaches of activating lymphocytes in vitro. We have studied the effect of anti-CD3 antibody on the in vitro activation of peripheral blood lymphocytes and tumor infiltrating lymphocytes (TIL) taken from pa...
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| Published in | Clinical immunology and immunopathology Vol. 50; no. 3; pp. 348 - 363 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
San Diego, CA
Elsevier Inc
01.03.1989
New York, NY Academic Press Boston |
| Subjects | |
| Online Access | Get full text |
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| Abstract | The current interest in adoptive immunotherapy of cancer has stimulated research into novel approaches of activating lymphocytes
in vitro. We have studied the effect of anti-CD3 antibody on the
in vitro activation of peripheral blood lymphocytes and tumor infiltrating lymphocytes (TIL) taken from patients with nonsmall cell cancer of the lung (NSCC). We demonstrate that anti-CD3 substantially enhances the proliferative response and bulk culture growth of interleukin 2 (IL-2)-activated killer cells. The addition of anti-CD3 to IL-2-treated TIL enhances their cytotoxicity against fresh autologous NSCC tumor targets, but not against the cancer cell lines K562 and M14. The effectors generated by culture in IL-2 and anti-CD3 have greatly increased IL-2 receptor expression and are predominantly CD4+ cells. These results establish anti-CD3 as a potentially powerful agent in the
in vitro activation of lymphocytes from cancer patients. |
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| AbstractList | The current interest in adoptive immunotherapy of cancer has stimulated research into novel approaches of activating lymphocytes in vitro. The authors have studied the effect of anti-CD3 antibody on the in vitro activation of peripheral blood lymphocytes and tumor infiltrating lymphocytes (TIL) taken from patients with nonsmall cell cancer of the lung (NSCC). They demonstrate that anti-CD3 substantially enhances the proliferative response and bulk culture growth of interleukin 2 (IL-2)-activated killer cells. The results establish anti-CD3 as a potentially powerful agent in the in vitro activation of lymphocytes from cancer patients. The current interest in adoptive immunotherapy of cancer has stimulated research into novel approaches of activating lymphocytes in vitro. We have studied the effect of anti-CD3 antibody on the in vitro activation of peripheral blood lymphocytes and tumor infiltrating lymphocytes (TIL) taken from patients with nonsmall cell cancer of the lung (NSCC). We demonstrate that anti-CD3 substantially enhances the proliferative response and bulk culture growth of interleukin 2 (IL-2)-activated killer cells. The addition of anti-CD3 to IL-2-treated TIL enhances their cytotoxicity against fresh autologous NSCC tumor targets, but not against the cancer cell lines K562 and M14. The effectors generated by culture in IL-2 and anti-CD3 have greatly increased IL-2 receptor expression and are predominantly CD4+ cells. These results establish anti-CD3 as a potentially powerful agent in the in vitro activation of lymphocytes from cancer patients. The current interest in adoptive immunotherapy of cancer has stimulated research into novel approaches of activating lymphocytes in vitro. We have studied the effect of anti-CD3 antibody on the in vitro activation of peripheral blood lymphocytes and tumor infiltrating lymphocytes (TIL) taken from patients with nonsmall cell cancer of the lung (NSCC). We demonstrate that anti-CD3 substantially enhances the proliferative response and bulk culture growth of interleukin 2 (IL-2)-activated killer cells. The addition of anti-CD3 to IL-2-treated TIL enhances their cytotoxicity against fresh autologous NSCC tumor targets, but not against the cancer cell lines K562 and M14. The effectors generated by culture in IL-2 and anti-CD3 have greatly increased IL-2 receptor expression and are predominantly CD4+ cells. These results establish anti-CD3 as a potentially powerful agent in the in vitro activation of lymphocytes from cancer patients. |
| Author | Leibson, Paul J. McKean, David J. Pisani, Richard J. |
| Author_xml | – sequence: 1 givenname: Richard J. surname: Pisani fullname: Pisani, Richard J. organization: Division of Thoracic Diseases, Mayo Clinic, Rochester, Minnesota 55905 USA – sequence: 2 givenname: Paul J. surname: Leibson fullname: Leibson, Paul J. organization: Division of Thoracic Diseases, Mayo Clinic, Rochester, Minnesota 55905 USA – sequence: 3 givenname: David J. surname: McKean fullname: McKean, David J. organization: Division of Thoracic Diseases, Mayo Clinic, Rochester, Minnesota 55905 USA |
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| Cites_doi | 10.4049/jimmunol.130.2.958 10.1002/1097-0142(19850315)55:6<1327::AID-CNCR2820550628>3.0.CO;2-O 10.1007/BF00205646 10.1016/0161-5890(86)90153-7 10.1084/jem.155.6.1823 10.1007/BF00199837 10.1084/jem.166.2.303 10.1084/jem.155.1.83 10.1002/ijc.2910300202 10.1182/blood.V68.4.938.938 10.1002/ijc.2910290510 10.1002/ijc.2910370410 10.1016/0008-8749(85)90350-8 10.1056/NEJM198704093161501 10.1084/jem.164.3.814 10.1080/01616412.1986.11739735 10.1002/eji.1830161224 10.1016/0277-5379(82)90248-6 10.1016/0167-5699(85)90013-1 10.4049/jimmunol.139.2.639 10.1016/0145-2126(86)90273-0 |
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| Keywords | Human Interleukin 2 Respiratory disease Tumor Activation Monoclonal antibody In vitro Lymphocyte Bronchopulmonary Non small cell carcinoma |
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| Snippet | The current interest in adoptive immunotherapy of cancer has stimulated research into novel approaches of activating lymphocytes
in vitro. We have studied the... The current interest in adoptive immunotherapy of cancer has stimulated research into novel approaches of activating lymphocytes in vitro. We have studied the... The current interest in adoptive immunotherapy of cancer has stimulated research into novel approaches of activating lymphocytes in vitro. The authors have... |
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| SubjectTerms | Aged Antibodies, Monoclonal - physiology Antigens, Differentiation, T-Lymphocyte - immunology Biological and medical sciences Carcinoma, Non-Small-Cell Lung - immunology Carcinoma, Non-Small-Cell Lung - pathology CD3 Complex Cell Movement Cells, Cultured Drug Combinations Female Humans Interleukin-2 - pharmacology Lung Neoplasms - immunology Lung Neoplasms - pathology Lymphocyte Activation Male Medical sciences Middle Aged Phenotype Pneumology Receptors, Antigen, T-Cell - immunology Recombinant Proteins - pharmacology T-Lymphocytes, Cytotoxic - classification T-Lymphocytes, Cytotoxic - pathology Tumors of the respiratory system and mediastinum |
| Title | In vitro activation of lymphocytes from nonsmall cell cancer patients by interleukin 2 and anti-CD3 antibody |
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