How chromatin remodelling allows shuffling of immunoglobulin heavy chain genes

• Published in: Molecular bioSystems Vol. 4; no. 8; pp. 790 - 798
• Main Authors: Bowen, Adam J, Corcoran, Anne E
• Format: Journal Article
• Language: English
• Published: England 01.01.2008
• Subjects: Animals; Cell Nucleus - metabolism; Chromatin - metabolism; Chromatin Assembly and Disassembly; Gene Rearrangement, B-Lymphocyte, Heavy Chain; Genes, Immunoglobulin; Histones - metabolism; Humans; Immunoglobulin Heavy Chains - genetics; Immunoglobulin Heavy Chains - immunology; Immunoglobulin Heavy Chains - metabolism; Immunoglobulin Variable Region - genetics; Immunoglobulin Variable Region - immunology; Immunoglobulin Variable Region - metabolism; Nucleosomes - metabolism; Recombination, Genetic; Transcription Factors - genetics; Transcription Factors - metabolism; Transcription, Genetic

Cellular identity is determined by the switching on and off of lineage-specific genes. This dynamic process is regulated by a highly co-ordinated series of chromatin remodelling mechanisms that control DNA accessibility to facilitate transcription, replication and recombination. The identity of an i...