Increased urinary interleukin 22 binding protein levels correlate with lupus nephritis activity

• Published in: Journal of rheumatology Vol. 41; no. 9; p. 1793
• Main Authors: Yang, Xuyan, Gao, Yin, Wang, Huiying, Zhao, Xiaoying, Gong, Xubo, Wang, Qingqing, Zhang, Xiaofei
• Format: Journal Article
• Language: English
• Published: Canada 01.09.2014
• Subjects: Adult; Biomarkers - urine; Cross-Sectional Studies; Female; Humans; Interleukin-22; Interleukins - urine; Lupus Nephritis - diagnosis; Lupus Nephritis - urine; Male; Middle Aged; Receptors, Interleukin - metabolism; Severity of Illness Index; IL-22 BINDING PROTEIN; INTERLEUKIN-22; RENAL ACTIVITY; SYSTEMIC LUPUS ERYTHEMATOSUS; LUPUS NEPHRITIS

Interleukin 22 (IL-22) plays an important role in the promotion of antimicrobial immunity. However, dysregulated IL-22 action leads to inflammation and is involved in autoimmune diseases, including systemic lupus erythematosus (SLE). IL-22 binding protein (IL-22BP) is a soluble inhibitory IL-22 rece...