The Genetics of Usher Syndrome in the Israeli and Palestinian Populations

• Published in: Investigative ophthalmology & visual science Vol. 59; no. 2; p. 1095
• Main Authors: Khalaileh, Ayat, Abu-Diab, Alaa, Ben-Yosef, Tamar, Raas-Rothschild, Annick, Lerer, Israela, Alswaiti, Yahya, Chowers, Itay, Banin, Eyal, Sharon, Dror, Khateb, Samer
• Format: Journal Article
• Language: English
• Published: United States 01.02.2018
• Subjects: Adult; Arabs; Child; Consanguinity; DNA Mutational Analysis; Ethnic Groups - genetics; Extracellular Matrix Proteins - genetics; Female; Founder Effect; Genetic Testing; Genotype; Humans; Israel; Male; Membrane Proteins - genetics; Mutation; Myosins - genetics; Pedigree; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Usher Syndromes - diagnosis; Usher Syndromes - genetics; Young Adult

Usher syndrome (USH) is the most common cause for deaf-blindness. It is genetically and clinically heterogeneous and prevalent in populations with high consanguinity rate. We aim to characterize the set of genes and mutations that cause USH in the Israeli and Palestinian populations. Seventy-four fa...