Effects of Acute Elevation in Blood Pressure and of Atropine on Heart Rate in Chagas' Disease A Preliminary Report

• Published in: Circulation (New York, N.Y.) Vol. 38; no. 2; pp. 289 - 294
• Main Authors: AMORIM, D. S., GODOY, R. A., MANÇO, J. C., TANAKA, A., GALLO, L.
• Format: Journal Article
• Language: English
• Published: United States 01.08.1968
• Subjects: Adult; Atropine - pharmacology; Blood Pressure - drug effects; Cardiac Output - drug effects; Cardiovascular System - physiopathology; Chagas Disease - complications; Chagas Disease - physiopathology; Heart Rate - drug effects; Humans; Metaraminol - pharmacology; Methacholine Compounds - pharmacology; Middle Aged; Sympathetic Nervous System - physiopathology

Degeneration of the parasympathetic ganglia in the heart and in the smooth muscle (esophagus, colon, and bronchi) is known to occur in Chagas' disease. The reflex bradycardia associated with acute elevation in systemic arterial pressure and the blocking of this reflex effect with atropine are u...