The role of the central renin-angiotensin system in Parkinson’s disease

• Published in: Journal of the renin-angiotensin-aldosterone system Vol. 11; no. 1; pp. 49 - 56
• Main Authors: Mertens, Birgit, Vanderheyden, Patrick, Michotte, Yvette, Sarre, Sophie
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.03.2010
• Subjects: Angiotensin II Type 1 Receptor Blockers - pharmacology; Angiotensin II Type 1 Receptor Blockers - therapeutic use; Angiotensin-Converting Enzyme Inhibitors - pharmacology; Angiotensin-Converting Enzyme Inhibitors - therapeutic use; Animals; Humans; Parkinson Disease - drug therapy; Parkinson Disease - physiopathology; Receptor, Angiotensin, Type 2 - metabolism; Renin-Angiotensin System - drug effects; Renin-Angiotensin System - physiology; angiotensin II type 1 receptor antagonists; angiotensin II type 2 receptor agonists; angiotensin-converting enzyme inhibitors; neuroprotection; Parkinson’s disease

Since the discovery of a renin-angiotensin system (RAS) in the brain, several studies have linked this central RAS to neurological disorders such as ischaemia, Alzheimer’s disease and depression. In the last decade, evidence has accumulated that the central RAS might also play a role in Parkinson’s...