Hypothermia Promotes Survival of Ischemic Retinal Ganglion Cells

• Published in: Investigative ophthalmology & visual science Vol. 57; no. 2; pp. 658 - 663
• Main Authors: Reinhard, Katja, Mutter, Marion, Gustafsson, Elisabeth, Gustafsson, Leon, Vaegler, Martin, Schultheiss, Maximilian, Müller, Sebastian, Yoeruek, Efdal, Schrader, Merle, Münch, Thomas A
• Format: Journal Article
• Language: English
• Published: United States 01.02.2016
• Subjects: Animals; Cadaver; Cell Count; Cell Death; Cell Survival; Disease Models, Animal; Humans; Hypothermia, Induced - methods; Ischemia - pathology; Ischemia - therapy; Retinal Diseases - pathology; Retinal Diseases - therapy; Retinal Ganglion Cells - pathology; Swine; Swine, Miniature

Ischemic stroke in retinal arteries leads to death of neural tissue and ultimately to blindness. The retina is known to die within 4 hours after onset of ischemia. It is debated whether hypothermia might increase the time window for medical treatment and thereby the chance of recovering sight. In or...