Restoration of Mitochondrial Integrity, Telomere Length, and Sensitivity to Oxidation by In Vitro Culture of Fuchs' Endothelial Corneal Dystrophy Cells

• Published in: Investigative ophthalmology & visual science Vol. 57; no. 14; p. 5926
• Main Authors: Gendron, Sébastien P., Thériault, Mathieu, Proulx, Stéphanie, Brunette, Isabelle, Rochette, Patrick J.
• Format: Journal Article
• Language: English
• Published: United States 01.11.2016
• Subjects: Antioxidants - pharmacology; Cells, Cultured; Descemet Membrane - cytology; Descemet Membrane - metabolism; DNA Damage - genetics; DNA, Mitochondrial - genetics; Endothelial Cells - drug effects; Endothelial Cells - radiation effects; Endothelium, Corneal - cytology; Endothelium, Corneal - metabolism; Female; Fuchs' Endothelial Dystrophy - genetics; Fuchs' Endothelial Dystrophy - physiopathology; Humans; Hydrogen Peroxide - pharmacology; Male; Mitochondria - genetics; Mitochondria - pathology; Oxidants - pharmacology; Oxidative Stress - physiology; Sequence Deletion; Telomere - physiology; Ultraviolet Rays

Fuchs' endothelial corneal dystrophy (FECD), a degenerative disease of the corneal endothelium that leads to vision loss, is a leading cause of corneal transplantation. The cause of this disease is still unknown, but the implication of oxidative stress is strongly suggested. In this study, we a...