The influence of collagen network integrity on the accumulation of gadolinium-based MR contrast agents in articular cartilage

• Published in: RöFo : Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebende Verfahren Vol. 183; no. 3; p. 226
• Main Authors: Wiener, E, Settles, M, Weirich, G, Schmidt, C, Diederichs, G
• Format: Journal Article
• Language: English
• Published: Germany 01.03.2011
• Subjects: Animals; Cartilage, Articular - pathology; Cattle; Collagen - metabolism; Contrast Media - pharmacokinetics; Gadolinium DTPA - pharmacokinetics; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Osteoarthritis - diagnosis; Patella - pathology; Proteoglycans - metabolism

Delayed gadolinium-enhanced MR imaging of cartilage is used to quantify the proteoglycan loss in early osteoarthritis. It is assumed that T1 after Gd-DTPA administration in the near equilibrium state reflects selective proteoglycan loss from cartilage. To investigate the influence of the collagen ne...