Driving motor cortex oscillations modulates bradykinesia in Parkinson’s disease

• Published in: Brain (London, England : 1878) Vol. 145; no. 1; pp. 224 - 236
• Main Authors: Guerra, Andrea, Colella, Donato, Giangrosso, Margherita, Cannavacciuolo, Antonio, Paparella, Giulia, Fabbrini, Giovanni, Suppa, Antonio, Berardelli, Alfredo, Bologna, Matteo
• Format: Journal Article
• Language: English
• Published: England 29.03.2022
• Subjects: Evoked Potentials, Motor - physiology; Gamma Rhythm - physiology; Humans; Hypokinesia - etiology; Motor Cortex; Parkinson Disease - complications; Transcranial Direct Current Stimulation - methods; motor cortex; bradykinesia; oscillations; GABA-A; Parkinson’s disease

In patients with Parkinson’s disease, beta (β) and gamma (γ) oscillations are altered in the basal ganglia, and this abnormality contributes to the pathophysiology of bradykinesia. However, it is unclear whether β and γ rhythms at the primary motor cortex (M1) level influence bradykinesia. Transcran...