Pertussis serosurveillance study in Izmir, Turkey

• Published in: Journal of tropical pediatrics (1980) Vol. 61; no. 1; p. 32
• Main Authors: Türkoglu, Ebru, Sönmez, Cemile, Kurugöl, Zafer, Çöplü, Nilay, Koturoğlu, Guldane
• Format: Journal Article
• Language: English
• Published: England 01.02.2015
• Subjects: Adhesins, Bacterial; Adolescent; Adult; Aged; Aged, 80 and over; Antibodies, Bacterial - blood; Bordetella pertussis - immunology; Bordetella pertussis - isolation & purification; Child; Child, Preschool; Enzyme-Linked Immunosorbent Assay; Female; Hemagglutinins - immunology; Humans; Immunoglobulin G - immunology; Immunoglobulin G - metabolism; Infant; Male; Middle Aged; Pertussis Toxin - immunology; Population Surveillance; Seroepidemiologic Studies; Turkey - epidemiology; Virulence Factors, Bordetella; Whooping Cough - blood; Whooping Cough - epidemiology; Young Adult; Turkey; serosurveillance; Bordetella pertussis; ELISA
• DOI: 10.1093/tropej/fmu062

Pertussis is a life-threatening, vaccine-preventable infection. Adults who can be asymptomatic may infect infants. The aim of this study is to determine the IgG antibody levels against pertussis toxin (PT) and filamentous hemagglutinin from 6 months to ≥60 years in Izmir, Turkey. A cluster sample design developed by Expanded Programme on Immunization of the World Health Organization was carried out for the selection of the study population, which consisted of 399 healthy subjects. In-house ELISA was studied in Turkish Public Health Institution. Antibody levels of <10 EU/ml, ≥10 EU/ml and ≥100 EU/ml were accepted as non-immune, immune and possible acute/recent infection, respectively. Anti-PT antibody levels were 8.5% <10 EU/ml, 68.2% 10-100 EU/ml and 23.3% ≥100 EU/ml; the latter was correlated with possible acute/recent infection. Results showed that pertussis is endemic, particularly among adolescents and adults, which is a threat for infants who have not completed their primary immunization.