Inhibition of Heme Uptake in Pseudomonas aeruginosa by its Hemophore (HasAp) Bound to Synthetic Metal Complexes

• Published in: Angewandte Chemie Vol. 126; no. 11; pp. 2906 - 2910
• Main Authors: Shirataki, Chikako, Shoji, Osami, Terada, Mitsuyoshi, Ozaki, Shin-ichi, Sugimoto, Hiroshi, Shiro, Yoshitsugu, Watanabe, Yoshihito
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 10.03.2014; WILEY‐VCH Verlag; Wiley Subscription Services, Inc
• Subjects: Acquisitions; Chemistry; Crystal structure; Eisenkomplexe; HasA; Häm-Proteine; Iron; Marketing; Metals; Monitoring; Proteinstrukturen; Pseudomonas aeruginosa; Synthetic metals; Uptakes; Wachstumshemmer

The heme acquisition system A protein secreted by Pseudomonas aeruginosa (HasAp) can capture several synthetic metal complexes other than heme. The crystal structures of HasAp harboring synthetic metal complexes revealed only small perturbation of the overall HasAp structure. An inhibitory effect up...