Relative contribution of iron burden, HFE mutations, and insulin resistance to fibrosis in nonalcoholic fatty liver

• Published in: Hepatology (Baltimore, Md.) Vol. 39; no. 1; pp. 179 - 187
• Main Authors: Bugianesi, Elisabetta, Manzini, Paola, D'Antico, Sergio, Vanni, Ester, Longo, Filomena, Leone, Nicola, Massarenti, Paola, Piga, Antonio, Marchesini, Giulio, Rizzetto, Mario
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.01.2004; Wiley
• Subjects: Adult; Biological and medical sciences; Fatty Liver - epidemiology; Fatty Liver - pathology; Fatty Liver - physiopathology; Female; Gastroenterology. Liver. Pancreas. Abdomen; Hemochromatosis Protein; Histocompatibility Antigens Class I - genetics; Humans; Insulin Resistance; Iron - blood; Iron Overload - epidemiology; Iron Overload - pathology; Iron Overload - physiopathology; Liver - pathology; Liver Cirrhosis - epidemiology; Liver Cirrhosis - pathology; Liver Cirrhosis - physiopathology; Male; Medical sciences; Membrane Proteins - genetics; Middle Aged; Point Mutation; Prevalence; Severity of Illness Index; Target tissue resistance; Liver; Fibrosis; Gastroenterology; Iron; Mutation; Insulin

The mechanism(s) determining the progression from fatty liver to steatohepatitis is currently unknown. Our goal was to define the relative impact of iron overload, genetic mutations of HFE, and insulin resistance on the severity of liver fibrosis in a population of subjects with nonalcoholic fatty l...