Gallic acid ameliorates thymic involution via activating Sox2 and Nanog

• Published in: Scandinavian journal of immunology Vol. 96; no. 3
• Main Authors: Guo, Li, Cao, Jia‐hui, Cheng, Deng‐wei, Dong, Han, You, Li, Sun, Yun, Ding, Yi, Chai, Yu‐rong
• Format: Journal Article
• Language: English
• Published: Oxford Wiley Subscription Services, Inc 01.09.2022
• Subjects: Acids; Aging; Atrophy; Epithelial cells; Galactose; Gallic acid; Homeobox; Medulla oblongata; Nanog; Natural products; Organogenesis; Pluripotency; Polyphenols; Progenitor cells; regeneration; Sox2; Stem cell transplantation; Stem cells; Thymic involution; Thymus; Thymus gland; Transcription factors

Thymic ageing precedes other organs, which is mainly caused by the gradual loss of thymic epithelial cells, and the thymic epithelial progenitor cells have been found in human and adult mouse. Stem cell transcription factors, sex‐determining region Y‐box2 (Sox2) is strongly involved in organogenesis...