Pharmacological profile of adenosine A2 receptor in PC12 cells

• Published in: Life sciences (1973) Vol. 39; no. 12; p. 1059
• Main Authors: Noronha-Blob, L, Marshall, R P, Kinnier, W J, U'Prichard, D C
• Format: Journal Article
• Language: English
• Published: Netherlands 22.09.1986
• Subjects: Adenosine - analogs & derivatives; Adenosine - pharmacology; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases - analysis; Adrenal Gland Neoplasms - analysis; Animals; Cell Line; Cell Membrane - enzymology; Colforsin - antagonists & inhibitors; Colforsin - pharmacology; Membrane Proteins - analysis; Neoplasm Proteins - analysis; Pheochromocytoma - analysis; Rats; Receptors, Cell Surface - classification; Receptors, Cell Surface - drug effects; Receptors, Purinergic; Stimulation, Chemical

The PC12 cell line, a clone isolated from a pheochromocytoma tumor of rat adrenal medulla, was shown to exclusively contain stimulatory adenosine (A2) receptors linked to adenylate cyclase (AC). AC was stimulated 6-7 fold by several agonists with a rank order of potency of 5'-N-Ethyl carboxamid...