Genomics of selected human odorant receptors

Single nucleotide polymorphisms (SNPs) in odorant receptor genes may influence the protein sequence and consequently also the function of the receptors. An analysis of the HapMap data for human OR3A1 was performed and provided evidence that genetic differences subject to ancestry and gender can be r...

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Bibliographic Details
Published inMonatshefte für Chemie Vol. 139; no. 12; pp. 1537 - 1544
Main Authors Knape, Kirsten, Beyer, Anton, Stary, Anna, Buchbauer, Gerhard, Wolschann, Peter
Format Journal Article
LanguageEnglish
Published Vienna Springer-Verlag 01.12.2008
Subjects
Analytical Chemistry
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Inorganic Chemistry
Organic Chemistry
Physical Chemistry
Theoretical and Computational Chemistry
Odorant receptor; OR3A1; Genomics; Single nucleotide polymorphism
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Summary:Single nucleotide polymorphisms (SNPs) in odorant receptor genes may influence the protein sequence and consequently also the function of the receptors. An analysis of the HapMap data for human OR3A1 was performed and provided evidence that genetic differences subject to ancestry and gender can be recognized. A genomic comparison of individuals shows the diversity of odorant receptor genes and therefore potentially the variety of the sense of smell. At this time, two complete human genomes are available in public domain, which we used for this purpose.
ISSN:0026-9247
1434-4475
DOI:10.1007/s00706-008-0957-6