Compartmentalized Human Immunodeficiency Virus Type 1 Reservoir in Intestinal Monocytes/Macrophages on Antiretroviral Therapy

• Published in: The Journal of infectious diseases Vol. 231; no. 3; pp. 611 - 621
• Main Authors: Vellas, Camille, Martres, Dorine, Requena, Mary, Nayrac, Manon, Collercandy, Nived, Latour, Justine, Barange, Karl, Alric, Laurent, Martin-Blondel, Guillaume, Izopet, Jacques, Lagane, Bernard, Delobel, Pierre
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 17.03.2025
• Subjects: Adult; Anti-Retroviral Agents; Anti-Retroviral Agents - therapeutic use; CD4-Positive T-Lymphocytes; CD4-Positive T-Lymphocytes - virology; Colon; DNA, Viral; Duodenum; Female; HIV Infections; HIV Infections - drug therapy; HIV Infections - virology; HIV-1; HIV-1 - genetics; HIV-1 - isolation & purification; HIV-1 - physiology; Humans; Intestinal Mucosa; Intestinal Mucosa - virology; Life Sciences; Macrophages; Macrophages - virology; Male; Middle Aged; Monocytes; Monocytes - virology; Proviruses; Proviruses - genetics; Proviruses - isolation & purification; Viral Load; HIV-1; persistence; provirus; gut; monocytes-macrophages

The intestinal mucosa contains many cells targeted by human immunodeficiency virus type 1 (HIV-1), and high levels of HIV-1 DNA persist in this compartment under antiretroviral therapy (ART). While CD4+ T cells are the best-characterized reservoir of HIV-1, the role of long-lived intestinal macropha...