Acute peripheral tissue effects of ghrelin on interstitial levels of glucose, glycerol, and lactate: a microdialysis study in healthy human subjects

• Published in: American journal of physiology: endocrinology and metabolism Vol. 304; no. 12; pp. E1273 - E1280
• Main Authors: Vestergaard, Esben Thyssen, Møller, Niels, Jørgensen, Jens Otto Lunde
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 15.06.2013
• Subjects: Adipose tissue; Adipose Tissue - drug effects; Adipose Tissue - metabolism; Administration, Oral; Blood Glucose - drug effects; Blood Glucose - metabolism; Effects; Extracellular Fluid - drug effects; Extracellular Fluid - metabolism; Fatty Acids, Nonesterified - blood; Ghrelin - administration & dosage; Ghrelin - blood; Glucose; Glucose - metabolism; Glucose Clamp Technique; Glycerol - metabolism; Humans; Hyperinsulinism - drug therapy; Hyperinsulinism - metabolism; Insulin resistance; Insulin Resistance - physiology; Lactic Acid - metabolism; Ligands; Male; Metabolism; Microdialysis; Muscle, Skeletal - drug effects; Muscle, Skeletal - metabolism; Second Messenger Systems - physiology; Single-Blind Method; Tissues; Young Adult; microdialysis; lipolysis; glucose metabolism; acyl-ghrelin

Ghrelin is a gut-derived peptide and an endogenous ligand for the ghrelin receptor. Intravenous infusion of ghrelin induces insulin resistance and hyperglycemia and increases circulating levels of nonesterified free fatty acids. Our objective was to investigate whether the metabolic effects are medi...