Efficient one-pot synthesis of trans-Pt( ii )(salicylaldimine)(4-picoline)Cl complexes: effective agents for enhanced expression of p53 tumor suppressor genes

• Published in: Dalton transactions : an international journal of inorganic chemistry Vol. 44; no. 21; pp. 9872 - 9880
• Main Authors: Rahman, Faiz-Ur, Ali, Amjad, Guo, Rong, Wang, Wei-Kun, Wang, Hui, Li, Zhan-Ting, Lin, Yuejian, Zhang, Dan-Wei
• Format: Journal Article Web Resource
• Language: English
• Published: England Royal Society of Chemistry (RSC) 07.06.2015
• Subjects: Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Caspase 3 - metabolism; Caspase 9 - metabolism; Cell Line, Tumor; Cell Survival - drug effects; Chemistry; Chimie; DNA - metabolism; Gene Expression - drug effects; Humans; Organoplatinum Compounds - chemistry; Organoplatinum Compounds - pharmacology; Physical, chemical, mathematical & earth Sciences; Physique, chimie, mathématiques & sciences de la terre; Salicylates - chemistry; Tumor Suppressor Protein p53 - genetics

A series of trans -Pt( ii )(salicylaldimine)(4-picoline)Cl complexes were synthesized in 78–87% yield using a one-pot procedure from commercially available precursors. The structures of these complexes were characterized by 1 H, 19 F and 13 C NMR spectroscopy, HRMS (ESI) as well as single crystal X-...