Efficient one-pot synthesis of trans-Pt( ii )(salicylaldimine)(4-picoline)Cl complexes: effective agents for enhanced expression of p53 tumor suppressor genes

A series of trans -Pt( ii )(salicylaldimine)(4-picoline)Cl complexes were synthesized in 78–87% yield using a one-pot procedure from commercially available precursors. The structures of these complexes were characterized by 1 H, 19 F and 13 C NMR spectroscopy, HRMS (ESI) as well as single crystal X-...

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Published inDalton transactions : an international journal of inorganic chemistry Vol. 44; no. 21; pp. 9872 - 9880
Main Authors Rahman, Faiz-Ur, Ali, Amjad, Guo, Rong, Wang, Wei-Kun, Wang, Hui, Li, Zhan-Ting, Lin, Yuejian, Zhang, Dan-Wei
Format Journal Article Web Resource
LanguageEnglish
Published England Royal Society of Chemistry (RSC) 07.06.2015
Subjects
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Caspase 3 - metabolism
Caspase 9 - metabolism
Cell Line, Tumor
Cell Survival - drug effects
Chemistry
Chimie
DNA - metabolism
Gene Expression - drug effects
Humans
Organoplatinum Compounds - chemistry
Organoplatinum Compounds - pharmacology
Physical, chemical, mathematical & earth Sciences
Physique, chimie, mathématiques & sciences de la terre
Salicylates - chemistry
Tumor Suppressor Protein p53 - genetics
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Abstract A series of trans -Pt( ii )(salicylaldimine)(4-picoline)Cl complexes were synthesized in 78–87% yield using a one-pot procedure from commercially available precursors. The structures of these complexes were characterized by 1 H, 19 F and 13 C NMR spectroscopy, HRMS (ESI) as well as single crystal X-ray analysis. Bioactivity investigations including bio-assay, time- and dose-dependent, cell cycle progression study, caspase 3 and 9 apoptosis marker assay and DNA interaction using pBR322 plasmid DNA by gel electrophoresis were performed. The results indicated that the complexes showed promising in vitro cytotoxicity in MCF-7 and A549 cancer cell lines. Moreover these complexes enhanced the expression of p53 tumor suppressor gene family members such as p63 and p73.
AbstractList A series of trans -Pt( ii )(salicylaldimine)(4-picoline)Cl complexes were synthesized in 78–87% yield using a one-pot procedure from commercially available precursors. The structures of these complexes were characterized by 1 H, 19 F and 13 C NMR spectroscopy, HRMS (ESI) as well as single crystal X-ray analysis. Bioactivity investigations including bio-assay, time- and dose-dependent, cell cycle progression study, caspase 3 and 9 apoptosis marker assay and DNA interaction using pBR322 plasmid DNA by gel electrophoresis were performed. The results indicated that the complexes showed promising in vitro cytotoxicity in MCF-7 and A549 cancer cell lines. Moreover these complexes enhanced the expression of p53 tumor suppressor gene family members such as p63 and p73.
A series of trans-Pt(II)(salicylaldimine)(4-picoline)Cl complexes were synthesized in 78-87% yield using a one-pot procedure from commercially available precursors. The structures of these complexes were characterized by (1)H, (19)F and (13)C NMR spectroscopy, HRMS (ESI) as well as single crystal X-ray analysis. Bioactivity investigations including bio-assay, time- and dose-dependent, cell cycle progression study, caspase 3 and 9 apoptosis marker assay and DNA interaction using pBR322 plasmid DNA by gel electrophoresis were performed. The results indicated that the complexes showed promising in vitro cytotoxicity in MCF-7 and A549 cancer cell lines. Moreover these complexes enhanced the expression of p53 tumor suppressor gene family members such as p63 and p73.
A series of trans-Pt(II)(salicylaldimine)(4-picoline)Cl complexes were synthesized in 78‒87% yield using one-pot procedure from commercially available precursors. The structures of these complexes were characterized by 1H, 19F and 13C NMR spectroscopy, HRMS (ESI) as well as single crystal X-ray analysis. Bioactivity investigations including bio-assay, time- and dosedependent, cell cycle progression study, caspase 3 and 9 apoptosis marker assay and DNA interaction using pBR322 plasmid DNA by gel electrophoresis were performed. The results indicated that the complexes showed promising in vitro cytotoxicity in MCF-7 and A549 cancer cell lines. Moreover these complexes enhanced the expression of p53 tumor suppressor gene family members such as p63 and p73.
A series of trans-Pt(II)(salicylaldimine)(4-picoline)Cl complexes were synthesized in 78-87% yield using a one-pot procedure from commercially available precursors. The structures of these complexes were characterized by (1)H, (19)F and (13)C NMR spectroscopy, HRMS (ESI) as well as single crystal X-ray analysis. Bioactivity investigations including bio-assay, time- and dose-dependent, cell cycle progression study, caspase 3 and 9 apoptosis marker assay and DNA interaction using pBR322 plasmid DNA by gel electrophoresis were performed. The results indicated that the complexes showed promising in vitro cytotoxicity in MCF-7 and A549 cancer cell lines. Moreover these complexes enhanced the expression of p53 tumor suppressor gene family members such as p63 and p73.A series of trans-Pt(II)(salicylaldimine)(4-picoline)Cl complexes were synthesized in 78-87% yield using a one-pot procedure from commercially available precursors. The structures of these complexes were characterized by (1)H, (19)F and (13)C NMR spectroscopy, HRMS (ESI) as well as single crystal X-ray analysis. Bioactivity investigations including bio-assay, time- and dose-dependent, cell cycle progression study, caspase 3 and 9 apoptosis marker assay and DNA interaction using pBR322 plasmid DNA by gel electrophoresis were performed. The results indicated that the complexes showed promising in vitro cytotoxicity in MCF-7 and A549 cancer cell lines. Moreover these complexes enhanced the expression of p53 tumor suppressor gene family members such as p63 and p73.
Author Rahman, Faiz-Ur
Zhang, Dan-Wei
Li, Zhan-Ting
Lin, Yuejian
Wang, Hui
Ali, Amjad
Guo, Rong
Wang, Wei-Kun
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/25939861$$D View this record in MEDLINE/PubMed
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Snippet A series of trans -Pt( ii )(salicylaldimine)(4-picoline)Cl complexes were synthesized in 78–87% yield using a one-pot procedure from commercially available...
A series of trans-Pt(II)(salicylaldimine)(4-picoline)Cl complexes were synthesized in 78-87% yield using a one-pot procedure from commercially available...
A series of trans-Pt(II)(salicylaldimine)(4-picoline)Cl complexes were synthesized in 78‒87% yield using one-pot procedure from commercially available...
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SubjectTerms Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Caspase 3 - metabolism
Caspase 9 - metabolism
Cell Line, Tumor
Cell Survival - drug effects
Chemistry
Chimie
DNA - metabolism
Gene Expression - drug effects
Humans
Organoplatinum Compounds - chemistry
Organoplatinum Compounds - pharmacology
Physical, chemical, mathematical & earth Sciences
Physique, chimie, mathématiques & sciences de la terre
Salicylates - chemistry
Tumor Suppressor Protein p53 - genetics
Title Efficient one-pot synthesis of trans-Pt( ii )(salicylaldimine)(4-picoline)Cl complexes: effective agents for enhanced expression of p53 tumor suppressor genes
URI https://www.ncbi.nlm.nih.gov/pubmed/25939861
https://www.proquest.com/docview/1682887121
http://orbi.ulg.ac.be/handle/2268/182211
Volume 44
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