Rapid onset of small intestinal perforation after successful steroid treatment in eosinophilic granulomatosis with polyangiitis

Eosinophilic granulomatosis with polyangiitis (EGPA) is a disorder characterized by extravascular granulomas, hypereosinophilia, and pulmonary and systemic small-vessel vasculitis. Bowel perforation is a rare but often fatal complication of EGPA. In the present report, we describe a case of small in...

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Bibliographic Details
Published inModern rheumatology Vol. 26; no. 6; pp. 968 - 970
Main Authors Ikeda, Keigo, Takasaki, Yoshinari, Sekigawa, Iwao
Format Journal Article
LanguageEnglish
Published United States 01.11.2016
Subjects
Adult
Female
Granulomatosis with Polyangiitis - complications
Granulomatosis with Polyangiitis - drug therapy
Humans
Intestinal Perforation - etiology
Steroids - therapeutic use
Intestinal perforation
EGPA
Necrotizing vasculitis
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Summary:Eosinophilic granulomatosis with polyangiitis (EGPA) is a disorder characterized by extravascular granulomas, hypereosinophilia, and pulmonary and systemic small-vessel vasculitis. Bowel perforation is a rare but often fatal complication of EGPA. In the present report, we describe a case of small intestinal perforation in a patient with EGPA. Through various examinations, we confirmed the presence of EGPA, and the patient responded well to steroid therapy. However, as the patient's condition subsequently worsened, the small intestine was consequently resected. The patient's overall condition improved thereafter. Thus, we believe that careful attention should be paid to intestinal symptoms and perforation in patients with EGPA.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
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ISSN:1439-7595
1439-7609
DOI:10.3109/14397595.2014.940126