The Use and Ethics of Digital Twins in Medicine

Digital Health Technologies (DHTs) are currently the subject of much debate both in terms of their technological frontiers as well as their ethical, legal and societal implications (ELSI). Regulation of such technologies as medical devices currently lacks behind their level of adoption. Digital Twin...

Full description

Saved in:
Bibliographic Details
Published inThe Journal of law, medicine & ethics Vol. 50; no. 3; pp. 583 - 596
Main Authors Iqbal, Jeffrey David, Krauthammer, Michael, Biller-Andorno, Nikola
Format Journal Article
LanguageEnglish
Published Boston Cambridge University Press 01.01.2022
Subjects
Online AccessGet full text

Cover

Loading…
Abstract Digital Health Technologies (DHTs) are currently the subject of much debate both in terms of their technological frontiers as well as their ethical, legal and societal implications (ELSI). Regulation of such technologies as medical devices currently lacks behind their level of adoption. Digital Twins are the next evolution step of such DHTs and provide an opportunity to anticipate and act on ELSI before adoption again leaps before the necessary review. This paper introduces the concept and use cases of digital twins in medicine, then frames the debate through the lens of related technologies, machine learning and personalized medicine, and maps ethical challenges stemming from those. Finally, we lay out how digital twins may change and challenge the future practice of medicine.
AbstractList Digital Health Technologies (DHTs) are currently the subject of much debate both in terms of their technological frontiers as well as their ethical, legal and societal implications (ELSI). Regulation of such technologies as medical devices currently lacks behind their level of adoption. Digital Twins are the next evolution step of such DHTs and provide an opportunity to anticipate and act on ELSI before adoption again leaps before the necessary review. This paper introduces the concept and use cases of digital twins in medicine, then frames the debate through the lens of related technologies, machine learning and personalized medicine, and maps ethical challenges stemming from those. Finally, we lay out how digital twins may change and challenge the future practice of medicine.
Digital Health Technologies (DHTs) are currently the subject of much debate both in terms of their technological frontiers as well as their ethical, legal and societal implications (ELSI). Regulation of such technologies as medical devices currently lacks behind their level of adoption. Digital Twins are the next evolution step of such DHTs and provide an opportunity to anticipate and act on ELSI before adoption again leaps before the necessary review. This paper introduces the concept and use cases of digital twins in medicine, then frames the debate through the lens of related technologies, machine learning and personalized medicine, and maps ethical challenges stemming from those. Finally, we lay out how digital twins may change and challenge the future practice of medicine.Digital Health Technologies (DHTs) are currently the subject of much debate both in terms of their technological frontiers as well as their ethical, legal and societal implications (ELSI). Regulation of such technologies as medical devices currently lacks behind their level of adoption. Digital Twins are the next evolution step of such DHTs and provide an opportunity to anticipate and act on ELSI before adoption again leaps before the necessary review. This paper introduces the concept and use cases of digital twins in medicine, then frames the debate through the lens of related technologies, machine learning and personalized medicine, and maps ethical challenges stemming from those. Finally, we lay out how digital twins may change and challenge the future practice of medicine.
Author Biller-Andorno, Nikola
Krauthammer, Michael
Iqbal, Jeffrey David
Author_xml – sequence: 1
  givenname: Jeffrey David
  surname: Iqbal
  fullname: Iqbal, Jeffrey David
– sequence: 2
  givenname: Michael
  surname: Krauthammer
  fullname: Krauthammer, Michael
– sequence: 3
  givenname: Nikola
  surname: Biller-Andorno
  fullname: Biller-Andorno, Nikola
BookMark eNpt0E1LAzEQBuAgFWyrJ_9AwIsg2-ZzszlKrR9Q8dKCt7A7O7Up22zdbBH_vSn1JJ5mDs8MM--IDEIbkJBrziaccTPd7nAimBATa87IkBtVZEaw90HqmZEZ50xfkFGMW8YYFzIfkulyg3QVkZahpvN-4yHSdk0f_Ifvy4Yuv3yI1Af6irUHH_CSnK_LJuLVbx2T1eN8OXvOFm9PL7P7RQZS8j6DGg0woapSgAJUVtsi18jQyqowphJVnSupVQ5W51yLNYBkOehkAblhckxuT3v3Xft5wNi7nY-ATVMGbA_RCSMLbjVXNtGbP3TbHrqQrjsqIxWXIk-KnxR0bYwdrh2kD3vfhr4rfeM4c8cIXYrQHSN01qSZuz8z-87vyu77X_0DH7pxfw
CitedBy_id crossref_primary_10_1007_s00405_024_08662_5
crossref_primary_10_46413_boneyusbad_1440963
crossref_primary_10_1213_ANE_0000000000006476
crossref_primary_10_1016_j_compind_2024_104230
crossref_primary_10_1111_jdv_19249
crossref_primary_10_1007_s12553_023_00798_4
crossref_primary_10_3390_jpm14030277
crossref_primary_10_1515_cclm_2023_0108
crossref_primary_10_1109_ACCESS_2023_3349379
crossref_primary_10_2196_50204
crossref_primary_10_3389_fdgth_2023_1253050
crossref_primary_10_1080_15265161_2024_2353029
crossref_primary_10_3390_jpm14050443
crossref_primary_10_3390_jpm14111101
crossref_primary_10_3390_app13137940
crossref_primary_10_1016_j_smhl_2025_100541
crossref_primary_10_1038_s41540_024_00450_5
crossref_primary_10_1080_15265161_2023_2237462
crossref_primary_10_1016_j_iot_2024_101379
crossref_primary_10_1016_j_piel_2023_11_002
crossref_primary_10_3390_cancers16223817
crossref_primary_10_57224_jhpr_1342561
ContentType Journal Article
Copyright 2022 The Author(s)
Copyright_xml – notice: 2022 The Author(s)
DBID AAYXX
CITATION
0-V
3V.
7RV
7TQ
7X7
7XB
88C
88E
88I
8AF
8AM
8C1
8FI
8FJ
8FK
8G5
AABKS
ABSDQ
ABUWG
AFKRA
ALSLI
AVQMV
AZQEC
BEC
BENPR
BGRYB
CCPQU
DHY
DON
DPSOV
DWQXO
FYUFA
GHDGH
GNUQQ
GUQSH
HCIFZ
K50
K7.
K9.
KB0
KC-
M0O
M0S
M0T
M1D
M1P
M2L
M2O
M2P
MBDVC
NAPCQ
PEJEM
PGAAH
PHGZM
PHGZT
PJZUB
PKEHL
PMKZF
PPXIY
PQEST
PQQKQ
PQUKI
PRINS
PRQQA
Q9U
S0X
7X8
DOI 10.1017/jme.2022.97
DatabaseName CrossRef
ProQuest Social Sciences Premium Collection
ProQuest Central (Corporate)
Nursing & Allied Health Database
PAIS Index
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Healthcare Administration Database (Alumni)
Medical Database (Alumni Edition)
Science Database (Alumni Edition)
STEM Database
Criminal Justice Database (Alumni Edition)
Public Health Database
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Research Library
Philosophy Collection
Philosophy Database
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
Social Science Premium Collection
Arts Premium Collection
ProQuest Central Essentials - QC
eLibrary
ProQuest Central
Criminology Collection
ProQuest One
PAIS International
PAIS International (Ovid)
Politics Collection
ProQuest Central Korea
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
ProQuest Research Library
SciTech Premium Collection
Art, Design & Architecture Collection
ProQuest Criminal Justice (Alumni)
ProQuest Health & Medical Complete (Alumni)
Nursing & Allied Health Database (Alumni Edition)
ProQuest Politics Collection
Criminal Justice Database
Health & Medical Collection (Alumni)
Healthcare Administration Database
Arts & Humanities Database
Medical Database
Political Science Database
Research Library
Science Database
Research Library (Corporate)
Nursing & Allied Health Premium
ProQuest One Visual Arts & Design
ProQuest One Religion & Philosophy
ProQuest Central Premium
ProQuest One Academic (New)
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest Digital Collections
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
ProQuest One Social Sciences
ProQuest Central Basic
SIRS Editorial
MEDLINE - Academic
DatabaseTitle CrossRef
Research Library Prep
ProQuest Central Student
ProQuest Central Essentials
elibrary
ProQuest AP Science
SciTech Premium Collection
ProQuest Central China
ProQuest One Religion & Philosophy
Philosophy Collection
Health Research Premium Collection
Arts Premium Collection
Health & Medical Research Collection
ProQuest Central (New)
ProQuest Medical Library (Alumni)
Social Science Premium Collection
ProQuest Political Science
ProQuest Science Journals (Alumni Edition)
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
ProQuest Hospital Collection (Alumni)
Nursing & Allied Health Premium
Criminology Collection
ProQuest Health & Medical Complete
Criminal Justice Periodicals (Alumni Edition)
ProQuest Social Sciences Premium Collection
ProQuest One Academic UKI Edition
PAIS International
ProQuest Health Management (Alumni Edition)
ProQuest Politics Collection
ProQuest Nursing & Allied Health Source (Alumni)
Arts & Humanities Full Text
ProQuest One Academic
ProQuest One Academic (New)
ProQuest One Academic Middle East (New)
SIRS Editorial
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
Research Library (Alumni Edition)
Politics Collection
ProQuest Central
ProQuest Health & Medical Research Collection
ProQuest Criminal Justice
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
ProQuest Research Library
ProQuest Art, Design and Architecture Collection
ProQuest Public Health
ProQuest One Social Sciences
ProQuest Central Basic
ProQuest Science Journals
ProQuest Health Management
ProQuest Nursing & Allied Health Source
ProQuest Digital Collections
ProQuest Criminal Justice (Alumni)
ProQuest Medical Library
ProQuest One Visual Arts & Design
ProQuest Central (Alumni)
Philosophy Database
MEDLINE - Academic
DatabaseTitleList Research Library Prep
CrossRef
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Public Health
Law
EISSN 1748-720X
EndPage 596
ExternalDocumentID 10_1017_jme_2022_97
GroupedDBID ---
-TM
.3N
.CB
.GA
.GJ
.Y3
0-V
05W
09C
09D
09E
0R~
10A
123
1OB
1OC
2-G
29K
31~
36B
4.4
50Y
50Z
51W
51X
52M
52N
52O
52P
52R
52S
52T
52W
52X
53G
5HH
5LA
5VS
66C
6DY
6PF
702
7LF
7PT
7RV
7X7
8-0
8-1
8-3
8-4
8-5
88E
88I
8AF
8C1
8FI
8FJ
8G5
8GL
8UM
930
96U
A01
A03
AABKS
AACLI
AAEVG
AAHHS
AAJPV
AAMNO
AANHP
AAOIO
AAONW
AARDL
AASVR
AAWTL
AAYXX
AAZKR
ABACO
ABAWP
ABBZL
ABCCA
ABCQN
ABEIX
ABEML
ABFWQ
ABGDZ
ABPPZ
ABPVW
ABSDQ
ABUWG
ABVAB
ABVKB
ABVZP
ABXAU
ABXHF
ACBMB
ACBWZ
ACCFJ
ACDLN
ACDSZ
ACDXX
ACFCP
ACGFS
ACGOD
ACHQT
ACQPF
ACRPL
ACSCC
ACXQS
ACYXJ
ACYZP
ADAZD
ADBBV
ADDNB
ADEBD
ADIYS
ADIZJ
ADKIL
ADNMO
ADUOI
ADVJH
AEBAK
AEEZP
AEFOJ
AEGXH
AEIMD
AENCP
AENEX
AEOBU
AEPLO
AEQDE
AEQLS
AEWDL
AEYHU
AFACB
AFBPY
AFEET
AFKRA
AFKRG
AFKRZ
AFXCU
AFZFC
AFZJQ
AGABE
AGHGI
AGJUD
AGQPQ
AGQRV
AGTDA
AHEHV
AHMBA
AHRGI
AIWBW
AJAOE
AJBDE
AJUZI
AKMAY
AL2
ALAGY
ALIPV
ALMA_UNASSIGNED_HOLDINGS
ALSLI
AMBMR
AOWSX
AQJOH
AQUVI
ARALO
ARTOV
ATUCA
ATUGU
AUTPY
AVQMV
AVWKF
AWSUU
AYAKG
AZBYB
AZFZN
AZQEC
AZVAB
BAFTC
BCR
BCU
BDDNI
BDRZF
BDZRT
BEC
BENPR
BGRYB
BHBCM
BHRNT
BKEYQ
BKOMP
BLC
BLZWO
BMSDO
BMVBW
BPHCQ
BROTX
BRXPI
BVXVI
BY8
CAG
CCPQU
CCQAD
CHEAL
CITATION
CJCSC
COF
D-6
D-7
D-E
D-F
D-I
DCZOG
DOPDO
DPSOV
DPXWK
DR2
DU5
DWQXO
EBS
EBX
ECV
EGQIC
EJD
EKAWT
EMOBN
ENX
EX3
F00
F01
F04
F5P
FEDTE
FM.
FYUFA
G-S
G.N
GCT
GICCO
GNUQQ
GODZA
GUQSH
H.X
H13
HCIFZ
HCSNT
HF~
HISYW
HMCUK
HOCAJ
HOLLA
HOVLH
HVGLF
HZI
HZ~
H~9
IAO
ICJ
IEA
IHR
IHW
ILT
INH
INR
IOF
IOO
IPO
IRE
ITC
IX1
J0M
J8X
K.F
K48
K50
KC-
LBL
LC2
LC3
LH4
LP6
LP7
LW6
LW7
LXB
LXHRH
LXL
LXN
LXO
LXY
M0O
M0T
M1D
M1P
M2L
M2O
M2P
M2Q
M86
MK4
N04
N05
N9A
NAPCQ
NF~
NXXTH
NZEOI
O9-
OHT
OIG
P2X
P2Z
P4B
P4D
PCD
PEA
PHGZM
PHGZT
PMKZF
PQQKQ
PROAC
PSQYO
Q.-
Q.N
Q11
Q1R
QB0
R.K
RCA
RHO
ROL
RWL
RX1
RXW
S0X
SAMSI
SAUOL
SCNPE
SFC
SJFOW
SSDHQ
SUPJJ
TAA
TAC
TAE
TAF
TLM
TQQ
TQW
TWJ
UB1
UFL
UKHRP
UNMZH
UXK
UXR
VKN
W2G
W8V
W99
WBKPD
WE1
WFFJZ
WH7
WOW
WQ9
WQJ
WXI
WXSBR
WYUIH
X6Y
XFL
XG1
XPM
YHZ
YQR
YYQ
YZZ
ZCG
ZGI
ZPPRI
ZRF
ZXP
ZYG
~32
~IA
~WT
~ZZ
3V.
7TQ
7XB
8FK
DHY
DON
K7.
K9.
MBDVC
PEJEM
PGAAH
PJZUB
PKEHL
PPXIY
PQEST
PQUKI
PRINS
PRQQA
Q9U
7X8
ID FETCH-LOGICAL-c331t-cde7c024ba2c4ce4959865e0e93b877b2bd643546c956152fcc306c54cece1703
IEDL.DBID 7X7
ISSN 1073-1105
1748-720X
IngestDate Fri Jul 11 06:05:11 EDT 2025
Sat Aug 16 21:25:22 EDT 2025
Thu Apr 24 23:05:40 EDT 2025
Tue Jul 01 00:59:10 EDT 2025
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 3
Language English
License https://creativecommons.org/licenses/by/4.0
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c331t-cde7c024ba2c4ce4959865e0e93b877b2bd643546c956152fcc306c54cece1703
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
OpenAccessLink https://www.cambridge.org/core/services/aop-cambridge-core/content/view/72AF8F41FF570DE7B8954E00DC22CEE9/S1073110522000973a.pdf/div-class-title-the-use-and-ethics-of-digital-twins-in-medicine-div.pdf
PQID 2737341326
PQPubID 48720
PageCount 14
ParticipantIDs proquest_miscellaneous_2738195149
proquest_journals_2737341326
crossref_citationtrail_10_1017_jme_2022_97
crossref_primary_10_1017_jme_2022_97
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2022-01-01
PublicationDateYYYYMMDD 2022-01-01
PublicationDate_xml – month: 01
  year: 2022
  text: 2022-01-01
  day: 01
PublicationDecade 2020
PublicationPlace Boston
PublicationPlace_xml – name: Boston
PublicationTitle The Journal of law, medicine & ethics
PublicationYear 2022
Publisher Cambridge University Press
Publisher_xml – name: Cambridge University Press
SSID ssj0001236
Score 2.4245098
Snippet Digital Health Technologies (DHTs) are currently the subject of much debate both in terms of their technological frontiers as well as their ethical, legal and...
SourceID proquest
crossref
SourceType Aggregation Database
Enrichment Source
Index Database
StartPage 583
SubjectTerms Adoption of innovations
Algorithms
Bioethics
Cardiovascular disease
Debates
Digital twins
Ethics
Finite volume method
Health care access
Heart
Machine learning
Medical equipment
Medical technology
Medicine
Patients
Pattern recognition
Precision medicine
Preventive maintenance
Robots
Software
Technology
Telemedicine
Title The Use and Ethics of Digital Twins in Medicine
URI https://www.proquest.com/docview/2737341326
https://www.proquest.com/docview/2738195149
Volume 50
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3dS8MwED_UgQgiOhXnFxH2JMStTdusT6L7YIgbMjbYW2nSVCbaTbfhv-9dm00F8aVQeqRwl9x3fgdQdeoqrjtpyGMlEu4pXedKCsFT4YaK4jGTg_r0-kF35D2M_bFNuM1tW-VKJ-aKOplqypHX0MxK0rhucDt75zQ1iqqrdoTGJpQIuoxauuR4HXDl8GRFz6HgaOZ8ez-PIKNf3ggj03VvCO3pp0X6rZBzK9PZhz3rHrK7Qp4HsGGyMmw-xp9l2O7ZMngZdotkGyvuEB1CDYXNRnPD4ixhRQc7m6asNXmmkSBs-DnJ5mySsdUKRzDqtIfNLreTELgWwllwnRip0Zqq2NWeNhjUhI3AN3UTCtWQUrkqQc_C9wJN91R9N9UaQwHtI602Dh7qY9jKppk5AWbQZXFk4FEs4QUxCiMJ_bQRBz66Ml4qKnC94kakLUw4Tat4jYp-MBkh6yJiXRTKClTXxLMCHeNvsvMVWyN7RObRt0ArcLX-jJubKhZxZqbLnIbqfBjFnf6_xBns0L-K3Mg5bC0-luYCvYWFusy3BD4bTecSSvft_tMA31oDF589p_UFNeO9mg
linkProvider ProQuest
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3dT9swED9BkQbShKCA6GDgSfCCZEjsJG4eJjTxoQItT63UtxA7Duq0pWxtVe2f4m_cXZx0Q0K88ZyTI53v7nfn-wI48j2den4e81TLjAfaeFwrKXkuRawpHrPlUJ_efdQZBLfDcLgEz3UvDJVV1jaxNNTZ2NAb-RnCrCKLK6Lzp1-ctkZRdrVeoeHE4s7-mWPINvl6c4n3eyzE9VX_osOrrQLcSOlPucmsMohMOhUmMBYDhLgdhdazsdRtpbTQGaJ0GESGej5DkRuDbrUJkdZYHxUEz12GFQRejzRKDRcBXjkOzdU4So6wGlb9gDSi-vtPmskpxClNl_ofAV8CQIlq1xuwXrmj7JuTn01YskUTlrvpvAkfelXavQkf3eMecz1LW3CGwsUGE8vSImOuYp6Nc3Y5eqQVJKw_HxUTNipYfcI2DN6FRzvQKMaF3QVm0UXyVRRQ7BJEKV5-Fod5O41CdJ2CXLbgpOZGYqqx5LQd40fi6s9UgqxLiHVJrFpwtCB-ctM4Xifbr9maVCo5Sf4JUAu-LD6jMlGGJC3seFbSUF4Ro8ZPbx9xCKudfq-bdG_u7_Zgjf7r3mX2oTH9PbOf0VOZ6oNSPBg8vLc8_gV0NvYG
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3dSxtBEB_8ABGkaKoYa3UL9kXYJrd7e5t7KEWMwW98MJC36-3enkT0oiYS-q_1r-vM7V2qIL75nGEPJr_ZmdmZ-Q3AXtA2aTvIY54amfHQ2DY3WkqeSxEbysdcSepzcRkd98PTgRrMwd96FobaKus7sbyos5GlN_IWullNN66IWnnVFnHV7f16eOS0QYoqrfU6DQ-RM_dniunb-OdJF__r70L0jq4Pj3m1YYBbKYMJt5nTFr2USYUNrcNkIe5EyrVdLE1HayNMhh5bhZGl-U8lcmsxxLYKZa0L0Fjw3HlY1FIFZGN6MEv2Smo03-8oObpYVc0GEl317T3xcwrxg5imXnrD186g9HC9VfhUhabswGNpDeZc0YD583TagKWLqgTfgBX_0Mf8_NJnaCHQWH_sWFpkzHfPs1HOusMbWkfCrqfDYsyGBatPWIf-h-hoAxaKUeE2gTkMlwIdhZTHhFGKQMhilXfSSGEYFeayCfu1NhJbUZTTpoy7xPei6QRVl5Dqklg3YW8m_OCZOd4W267VmlTmOU7-g6kJ32Y_o2FRtSQt3Oi5lKEaI2aQW-8fsQtLiMTk_OTy7Ass02f9E802LEyent1XDFomZqdEB4PfHw3Hf-JD-jw
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+Use+and+Ethics+of+Digital+Twins+in+Medicine&rft.jtitle=The+Journal+of+law%2C+medicine+%26+ethics&rft.au=Iqbal%2C+Jeffrey+David&rft.au=Krauthammer%2C+Michael&rft.au=Biller-Andorno%2C+Nikola&rft.date=2022-01-01&rft.pub=Cambridge+University+Press&rft.issn=1073-1105&rft.eissn=1748-720X&rft.volume=50&rft.issue=3&rft.spage=583&rft.epage=596&rft_id=info:doi/10.1017%2Fjme.2022.97&rft.externalDBID=HAS_PDF_LINK
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1073-1105&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1073-1105&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1073-1105&client=summon