How does iron-sulfur cluster coordination regulate the activity of human glutaredoxin 2?

• Published in: Antioxidants & redox signaling Vol. 9; no. 1; p. 151
• Main Authors: Berndt, Carsten, Hudemann, Christoph, Hanschmann, Eva-Maria, Axelsson, Rebecca, Holmgren, Arne, Lillig, Christopher Horst
• Format: Journal Article
• Language: English
• Published: United States 01.01.2007
• Subjects: Gene Expression Regulation; Glutaredoxins; Glutathione - metabolism; Humans; Iron-Sulfur Proteins - genetics; Iron-Sulfur Proteins - metabolism; Mitochondria - metabolism; Models, Biological; Mutagenesis, Site-Directed; Oxidoreductases - genetics; Oxidoreductases - metabolism

Human mitochondrial glutaredoxin (Grx2) was described as the first iron-sulfur protein from the thioredoxin superfamily of proteins. The [2Fe-2S] cluster was proposed to serve as redox sensor for the activation of Grx2 during oxidative stress. The authors have demonstrated that the iron-sulfur clust...