Microvascular response to metabolic and pressure challenge in the human coronary circulation

• Published in: American journal of physiology. Heart and circulatory physiology Vol. 301; no. 2; pp. H434 - H441
• Main Authors: de Marchi, Stefano F., Gloekler, Steffen, Rimoldi, Stefano F., Rölli, Patrizia, Steck, Hélène, Seiler, Christian
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.08.2011
• Subjects: Adaptation, Physiological; Adult; Analysis of Variance; Blood Pressure; Blood Volume; Cardiovascular system; Coronary Circulation; Coronary Vessels - physiology; Counterpulsation; Cross-Over Studies; Echocardiography, Doppler; Exercise; Exercise Test; Female; Hemodynamics; Homeostasis; Humans; Linear Models; Male; Manometry; Metabolism; Microcirculation; Microvessels - physiology; Myocardium - metabolism; Oxygen Consumption; Physiology; Stroke Volume; Switzerland; Vascular Resistance; Vasoconstriction; Ventricular Function, Left; Young Adult; Switzerland

In vivo observations of microcirculatory behavior during autoregulation and adaptation to varying myocardial oxygen demand are scarce in the human coronary system. This study assessed microvascular reactions to controlled metabolic and pressure provocation [bicycle exercise and external counterpulsa...