Congenital diaphragmatic hernia: phosphodiesterase-5 and Arginase inhibitors prevent pulmonary vascular hypoplasia in rat lungs

• Published in: Pediatric research Vol. 95; no. 4; pp. 941 - 948
• Main Authors: Toso, Alberto, Aránguiz, Oscar, Céspedes, Carlos, Navarrete, Orieta, Hernández, Cherie, Vio, Carlos P, Luco, Matías, Casanello, Paola, Kattan, Javier
• Format: Journal Article
• Language: English
• Published: United States Nature Publishing Group 01.03.2024
• Subjects: Animals; Arginase; Body mass index; Cyclic Nucleotide Phosphodiesterases, Type 5 - adverse effects; Disease Models, Animal; Female; Gene expression; Hernias; Hernias, Diaphragmatic, Congenital - pathology; Lung; Lungs; Phenyl Ethers - pharmacology; Pregnancy; Rats; Rats, Sprague-Dawley; Sildenafil Citrate - pharmacology; Sildenafil Citrate - therapeutic use; Smooth muscle

Severe pulmonary hypoplasia related to congenital diaphragmatic hernia (CDH) continues to be a potentially fatal condition despite advanced postnatal management strategies. To evaluate the effect of the antenatal sildenafil and 2(S)-amino-6-boronohexanoic acid (ABH-Arginase inhibitor) on lung volume...