The Breuer-Hering reflex in humans. Effects of pulmonary denervation and hypocapnia

• Published in: American journal of respiratory and critical care medicine Vol. 152; no. 1; p. 217
• Main Authors: Iber, C, Simon, P, Skatrud, J B, Mahowald, M W, Dempsey, J A
• Format: Journal Article
• Language: English
• Published: United States 01.07.1995
• Subjects: Adult; Afferent Pathways - physiology; Case-Control Studies; Female; Heart-Lung Transplantation - physiology; Humans; Hypocapnia - physiopathology; Lung - innervation; Lung Transplantation - physiology; Male; Polysomnography; Pulmonary Stretch Receptors - physiology; Reflex - physiology; Respiratory Mechanics - physiology; Sleep - physiology; Vagus Nerve - physiology; Ventilators, Negative-Pressure

Passive lung inflation in humans causes reflex expiratory prolongation that is abolished by vagal blockade. We have studied two aspects of this classic Breuer-Hering reflex in humans: the effect of pulmonary denervation from bilateral lung transplantation, and the effect of alveolar hypocapnia. Lung...