Reduced epithelial expression of secretory component in small airways correlates with airflow obstruction in chronic obstructive pulmonary disease

• Published in: American journal of respiratory and critical care medicine Vol. 163; no. 1; pp. 185 - 194
• Main Authors: PILETTE, Charles, GODDING, Veronique, KISS, Robert, DELOS, Monique, VERBEKEN, Eric, DECAESTECKER, Christine, DE PAEPE, Kristel, VAERMAN, Jean-Pierre, DECRAMER, Marc, SIBILLE, Yves
• Format: Journal Article
• Language: English
• Published: New York, NY American Lung Association 2001
• Subjects: Adolescent; Adult; Aged; Biological and medical sciences; Chronic obstructive pulmonary disease, asthma; Epithelium - metabolism; Female; Humans; Lung - metabolism; Lung Diseases, Obstructive - immunology; Lung Diseases, Obstructive - metabolism; Lung Diseases, Obstructive - physiopathology; Male; Medical sciences; Middle Aged; Neutrophil Infiltration; Pneumology; Protein Biosynthesis; Secretory Component - biosynthesis; Smoking - metabolism; Uteroglobin; Human; Chronic; Respiratory epithelium; Secretion; Infiltration; Obstructive pulmonary disease; Neutrophil

The epithelial polymeric immunoglobulin receptor/transmembrane secretory component (pIgR/SC) transports into secretions polymeric immunoglobulin A (pIgA), which is considered the first line of defense of the respiratory tract. The present study, done with quantitative immunohistochemistry, evaluated...