Dynamics of IFN-β Responses during Respiratory Viral Infection. Insights for Therapeutic Strategies

• Published in: American journal of respiratory and critical care medicine Vol. 201; no. 1; pp. 83 - 94
• Main Authors: Watson, Alastair, Spalluto, C. Mirella, McCrae, Christopher, Cellura, Doriana, Burke, Hannah, Cunoosamy, Danen, Freeman, Anna, Hicks, Alex, Hühn, Michael, Ostridge, Kristoffer, Staples, Karl J., Vaarala, Outi, Wilkinson, Tom
• Format: Journal Article
• Language: English
• Published: United States American Thoracic Society 01.01.2020
• Subjects: Adult; Aged; Aged, 80 and over; Antiviral Agents - therapeutic use; Antiviral drugs; Asthma; Asthma - drug therapy; Asthma - immunology; Asthma - virology; Chronic obstructive pulmonary disease; Female; Humans; Interferon-beta - therapeutic use; Male; Middle Aged; Pulmonary Disease, Chronic Obstructive - drug therapy; Pulmonary Disease, Chronic Obstructive - immunology; Pulmonary Disease, Chronic Obstructive - virology; Viral infections; Virus Diseases - drug therapy; Virus Diseases - immunology; innate immunity; respiratory viruses; chronic obstructive pulmonary disease; exacerbation

Viral infections are major drivers of exacerbations and clinical burden in patients with asthma and chronic obstructive pulmonary disease (COPD). IFN-β is a key component of the innate immune response to viral infection. To date, studies of inhaled IFN-β treatment have not demonstrated a significant...