Progesterone is extensively metabolized in osteoblasts: implications for progesterone action on bone

• Published in: Hormone and metabolic research Vol. 40; no. 10; p. 679
• Main Authors: Quinkler, M, Kaur, K, Hewison, M, Stewart, P M, Cooper, M S
• Format: Journal Article
• Language: English
• Published: Germany 01.10.2008
• Subjects: Aged; Bone and Bones - drug effects; Bone and Bones - metabolism; Cell Line, Tumor; Dexamethasone - pharmacology; Estradiol - pharmacology; Female; Gene Expression Regulation - drug effects; Humans; Male; Middle Aged; Osteoblasts - drug effects; Osteoblasts - enzymology; Osteoblasts - metabolism; Progesterone - chemistry; Progesterone - metabolism; RNA, Messenger - genetics; RNA, Messenger - metabolism

The effect of progestogens on bone is controversial with some studies suggesting an anabolic action while others show no effect. Prereceptor metabolism via localized expression of specific enzymes may have major impact on progesterone action in bone and may explain some of the discrepancies between...