Role for Neurokinin-2 Receptor in Interleukin-5-induced Airway Hyperresponsiveness but not Eosinophilia in Guinea Pigs

• Published in: American journal of respiratory and critical care medicine Vol. 156; no. 2; pp. 367 - 374
• Main Authors: KRANEVELD, ALETTA D., NIJKAMP, FRANS P., VAN OOSTERHOUT, ANTOON J. M.
• Format: Journal Article
• Language: English
• Published: New York, NY American Lung Association 01.08.1997
• Subjects: Airway Resistance - drug effects; Animals; Biological and medical sciences; Bronchial Hyperreactivity - chemically induced; Bronchial Hyperreactivity - physiopathology; Bronchoalveolar Lavage Fluid - cytology; Chronic obstructive pulmonary disease, asthma; Dipeptides - pharmacology; Eosinophilia - chemically induced; Eosinophilia - physiopathology; Eosinophils - cytology; Eosinophils - drug effects; Eosinophils - physiology; Guinea Pigs; Indoles - pharmacology; Interleukin-5 - pharmacology; Leukocyte Count - drug effects; Male; Medical sciences; Peptides, Cyclic - pharmacology; Pneumology; Receptors, Neurokinin-2 - antagonists & inhibitors; Receptors, Neurokinin-2 - drug effects; Receptors, Neurokinin-2 - physiology; Specific Pathogen-Free Organisms; Substance P - pharmacology; Immunopathology; Allergy; Neurokinin 2; Hyperreactivity; Respiratory disease; Pathogenesis; Cytokine; Hemopathy; Eosinophilia; Asthma; Pig; Respiratory tract; Vertebrata; Mammalia; Interleukin 5; Animal; Artiodactyla; Obstructive pulmonary disease; Ungulata

In the guinea pig, interleukin-5 (IL-5) has been shown to induce airway hyperresponsiveness as well as eosinophilia, which are important symptoms in asthma. IL-5 seems to be a critical cytokine since it selectively affects eosinophil functions. The mechanism of action by which IL-5 leads to airway h...