Evaluation of the clinical performance of anti-mutated citrullinated vimentin antibody and 14-3-3 eta testing in rheumatoid arthritis

• Published in: Clinical chemistry and laboratory medicine Vol. 63; no. 4; pp. 790 - 796
• Main Authors: Nelson, Heather A., Martins, Thomas B., Saadalla, Abdulrahman, Nandakumar, Vijayalakshmi
• Format: Journal Article
• Language: English
• Published: Germany De Gruyter 26.03.2025; Walter De Gruyter & Company
• Subjects: 14-3-3 eta; 14-3-3 protein; 14-3-3 Proteins - blood; 14-3-3 Proteins - immunology; Adult; Aged; Anti-Citrullinated Protein Antibodies - blood; Anti-Citrullinated Protein Antibodies - immunology; anti-MCV; Antibodies; anticyclic citrullinated peptide antibodies (CCP); Arthritis; Arthritis, Rheumatoid - blood; Arthritis, Rheumatoid - diagnosis; Arthritis, Rheumatoid - immunology; Autoantibodies - blood; Autoantibodies - immunology; Autoimmune diseases; Biomarkers - blood; Citrulline; Cohort analysis; Diagnosis; Diagnostics; Disease control; Female; Humans; Male; Middle Aged; Mutation; Patients; Retrospective Studies; Rheumatoid arthritis; rheumatoid factor; Rheumatoid Factor - blood; Sensitivity and Specificity; Serology; Vimentin; Vimentin - genetics; Vimentin - immunology; anticyclic citrullinated peptide antibodies (CCP); 14-3-3 eta; diagnosis; anti-MCV; rheumatoid factor

Early rheumatoid arthritis (RA) detection is crucial for improving patient prognosis. Anticyclic citrullinated peptide antibodies (anti-CCP) and rheumatoid factors (RF) support RA diagnosis but are undetectable in ∼20 % of cases. Recently, antibodies against mutated citrullinated vimentin (anti-MCV)...