Mouse strain differences in glutathione S-transferase activity and aflatoxin B1 biotransformation

• Published in: Toxicology letters Vol. 58; no. 1; p. 97
• Main Authors: Borroz, K I, Ramsdell, H S, Eaton, D L
• Format: Journal Article
• Language: English
• Published: Netherlands 01.09.1991
• Subjects: Aflatoxin B1; Aflatoxins - metabolism; Animals; Biotransformation; Carcinogens - metabolism; Cytosol - enzymology; Glutathione Transferase - metabolism; Isoenzymes - metabolism; Kinetics; Liver - enzymology; Male; Mice; Mice, Inbred Strains; Microsomes, Liver - enzymology; Species Specificity; Substrate Specificity

Previous studies have suggested that mice are resistant to the carcinogenic effects of aflatoxin B1 (AFB1) and that this resistance is largely the result of expression of an isoenzyme of glutathione S-transferase (GST) with high activity toward AFB1-8,9-epoxide. Significant interstrain differences i...